Discovery of a Unique Structural Motif in Lanthipeptide Synthetases for Substrate Binding and Interdomain Interactions

Class III lanthipeptide synthetases catalyze the formation of lanthionine/methyllanthionine and labionin crosslinks. We present here the 2.40 Å resolution structure of the kinase domain of a class III lanthipeptide synthetase CurKC from the biosynthesis of curvopeptin. A unique structural subunit fo...

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Detalles Bibliográficos
Autores principales: Huang, Shanqing, Wang, Ying, Cai, Chuangxu, Xiao, Xiuyun, Liu, Shulei, Ma, Yeying, Xie, Xiangqian, Liang, Yong, Chen, Hao, Zhu, Jiapeng, Hegemann, Julian D., Yao, Hongwei, Wei, Wanqing, Wang, Huan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9828337/
https://www.ncbi.nlm.nih.gov/pubmed/36102578
http://dx.doi.org/10.1002/anie.202211382

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