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The value of routine bone marrow examination in patients with extranodal NK/T‐cell lymphoma staged with PET/CT

BACKGROUND: Limited evidence supports the omission of routine bone marrow (BM) examination (biopsy and aspiration) in patients with nasal‐type extranodal NK/T‐cell lymphoma (ENKTCL). This study was aimed at assessing whether BM examination provides valuable information for positron emission tomograp...

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Autores principales: Yang, Yong, Wang, Ji‐Jin, Zhao, Rui‐Zhi, Huang, Cheng, Shi, Gui‐Qing, Zheng, Hao, Tang, Tian‐Lan, Liao, Si‐Qin, Chen, Jin‐Hua, Shen, Jian‐Zhen, Liu, Ting‐Bo, Xu, Ben‐Hua, Zhang, Yu‐Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9828511/
https://www.ncbi.nlm.nih.gov/pubmed/36181669
http://dx.doi.org/10.1002/cncr.34473
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author Yang, Yong
Wang, Ji‐Jin
Zhao, Rui‐Zhi
Huang, Cheng
Shi, Gui‐Qing
Zheng, Hao
Tang, Tian‐Lan
Liao, Si‐Qin
Chen, Jin‐Hua
Shen, Jian‐Zhen
Liu, Ting‐Bo
Xu, Ben‐Hua
Zhang, Yu‐Jing
author_facet Yang, Yong
Wang, Ji‐Jin
Zhao, Rui‐Zhi
Huang, Cheng
Shi, Gui‐Qing
Zheng, Hao
Tang, Tian‐Lan
Liao, Si‐Qin
Chen, Jin‐Hua
Shen, Jian‐Zhen
Liu, Ting‐Bo
Xu, Ben‐Hua
Zhang, Yu‐Jing
author_sort Yang, Yong
collection PubMed
description BACKGROUND: Limited evidence supports the omission of routine bone marrow (BM) examination (biopsy and aspiration) in patients with nasal‐type extranodal NK/T‐cell lymphoma (ENKTCL). This study was aimed at assessing whether BM examination provides valuable information for positron emission tomography/computed tomography (PET/CT)–based staging in this patient population. PATIENTS AND METHODS: Patients newly diagnosed with ENKTCL who underwent initial staging with both PET/CT and BM examination between 2013 and 2020 were retrospectively identified in two Chinese institutions. Overall, 742 patients were included; the BM examination was positive in 67 patients. RESULTS: Compared with BM biopsy alone, the combination of BM biopsy and aspiration assessment did not afford any additional diagnostic value. No patient with a positive BM biopsy was found to have early‐stage disease by PET/CT. BM biopsy or PET/CT led to upstaging from stage III to IV as a result of BM involvement in 21 patients. In 135 patients with distant organ involvement, BM involvement was associated with worse overall survival (OS) and progression‐free survival (PFS) compared with the corresponding durations in patients without BM involvement (2‐year OS: 35.9% vs. 60.4%, p < .001; PFS: 26% vs. 40.7%, p = .003). No difference in survival was noted between groups judged positive based on PET/CT and BM biopsy. CONCLUSION: Compared with aspiration, BM biopsy led to the detection of more BM lesions. Baseline PET/CT can be safely used to exclude BM involvement in early‐stage disease. Overall, routine BM examination affords diagnostic or prognostic value over PET/CT in patients with advanced‐stage nasal‐type ENKTCL.
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spelling pubmed-98285112023-01-10 The value of routine bone marrow examination in patients with extranodal NK/T‐cell lymphoma staged with PET/CT Yang, Yong Wang, Ji‐Jin Zhao, Rui‐Zhi Huang, Cheng Shi, Gui‐Qing Zheng, Hao Tang, Tian‐Lan Liao, Si‐Qin Chen, Jin‐Hua Shen, Jian‐Zhen Liu, Ting‐Bo Xu, Ben‐Hua Zhang, Yu‐Jing Cancer Original Articles BACKGROUND: Limited evidence supports the omission of routine bone marrow (BM) examination (biopsy and aspiration) in patients with nasal‐type extranodal NK/T‐cell lymphoma (ENKTCL). This study was aimed at assessing whether BM examination provides valuable information for positron emission tomography/computed tomography (PET/CT)–based staging in this patient population. PATIENTS AND METHODS: Patients newly diagnosed with ENKTCL who underwent initial staging with both PET/CT and BM examination between 2013 and 2020 were retrospectively identified in two Chinese institutions. Overall, 742 patients were included; the BM examination was positive in 67 patients. RESULTS: Compared with BM biopsy alone, the combination of BM biopsy and aspiration assessment did not afford any additional diagnostic value. No patient with a positive BM biopsy was found to have early‐stage disease by PET/CT. BM biopsy or PET/CT led to upstaging from stage III to IV as a result of BM involvement in 21 patients. In 135 patients with distant organ involvement, BM involvement was associated with worse overall survival (OS) and progression‐free survival (PFS) compared with the corresponding durations in patients without BM involvement (2‐year OS: 35.9% vs. 60.4%, p < .001; PFS: 26% vs. 40.7%, p = .003). No difference in survival was noted between groups judged positive based on PET/CT and BM biopsy. CONCLUSION: Compared with aspiration, BM biopsy led to the detection of more BM lesions. Baseline PET/CT can be safely used to exclude BM involvement in early‐stage disease. Overall, routine BM examination affords diagnostic or prognostic value over PET/CT in patients with advanced‐stage nasal‐type ENKTCL. John Wiley and Sons Inc. 2022-10-01 2022-11-15 /pmc/articles/PMC9828511/ /pubmed/36181669 http://dx.doi.org/10.1002/cncr.34473 Text en © 2022 The Authors. Cancer published by Wiley Periodicals LLC on behalf of American Cancer Society. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Original Articles
Yang, Yong
Wang, Ji‐Jin
Zhao, Rui‐Zhi
Huang, Cheng
Shi, Gui‐Qing
Zheng, Hao
Tang, Tian‐Lan
Liao, Si‐Qin
Chen, Jin‐Hua
Shen, Jian‐Zhen
Liu, Ting‐Bo
Xu, Ben‐Hua
Zhang, Yu‐Jing
The value of routine bone marrow examination in patients with extranodal NK/T‐cell lymphoma staged with PET/CT
title The value of routine bone marrow examination in patients with extranodal NK/T‐cell lymphoma staged with PET/CT
title_full The value of routine bone marrow examination in patients with extranodal NK/T‐cell lymphoma staged with PET/CT
title_fullStr The value of routine bone marrow examination in patients with extranodal NK/T‐cell lymphoma staged with PET/CT
title_full_unstemmed The value of routine bone marrow examination in patients with extranodal NK/T‐cell lymphoma staged with PET/CT
title_short The value of routine bone marrow examination in patients with extranodal NK/T‐cell lymphoma staged with PET/CT
title_sort value of routine bone marrow examination in patients with extranodal nk/t‐cell lymphoma staged with pet/ct
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9828511/
https://www.ncbi.nlm.nih.gov/pubmed/36181669
http://dx.doi.org/10.1002/cncr.34473
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