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Aryl Fluorosulfate Based Inhibitors That Covalently Target the SIRT5 Lysine Deacylase

The sirtuin enzymes are a family of lysine deacylases that regulate gene transcription and metabolism. Sirtuin 5 (SIRT5) hydrolyzes malonyl, succinyl, and glutaryl ϵ‐N‐carboxyacyllysine posttranslational modifications and has recently emerged as a vulnerability in certain cancers. However, chemical...

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Detalles Bibliográficos
Autores principales:	Bolding, Julie E., Martín‐Gago, Pablo, Rajabi, Nima, Gamon, Luke F., Hansen, Tobias N., Bartling, Christian R. O., Strømgaard, Kristian, Davies, Michael J., Olsen, Christian A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9828517/ https://www.ncbi.nlm.nih.gov/pubmed/36130196 http://dx.doi.org/10.1002/anie.202204565

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