The association of demographic and socioeconomic factors with COVID-19 during pre- and post-vaccination periods: A cross-sectional study of Virginia

Sociodemographic factors have been found to be associated with the transmission of coronavirus disease 2019 (COVID-19), yet most studies focused on the period before the proliferation of vaccination and obtained inconclusive results. In this cross-sectional study, the infections, deaths, incidence rates, case fatalities, and mortalities of Virginia’s 133 jurisdictions during the pre-vaccination and post-vaccination periods were compared, and their associations with demographic and socioeconomic factors were studied. The cumulative infections and deaths and medians of incidence rates, case fatalities, and mortalities of COVID-19 in 133 Virginia jurisdictions were significantly higher during the post-vaccination period than during the pre-vaccination period. A variety of demographic and socioeconomic risk factors were significantly associated with COVID-19 prevalence in Virginia. Multiple linear regression analysis suggested that demographic and socioeconomic factors contributed up to 80% of the variation in the infections, deaths, and incidence rates and up to 53% of the variation in the case fatalities and mortalities of COVID-19 in Virginia. The demographic and socioeconomic determinants differed during the pre- and post-vaccination periods. The developed multiple linear regression models could be used to effectively characterize the impact of demographic and socioeconomic factors on the infections, deaths, and incidence rates of COVID-19 in Virginia.