GluN2A‐Selective NMDA Receptor Antagonists: Mimicking the U‐Shaped Bioactive Conformation of TCN‐201 by a [2.2]Paracyclophane System

Under physiological conditions, N‐Methyl‐D‐Aspartate (NMDA) receptors play a crucial role for synaptic plasticity, long‐term potentiation and long‐term depression. However, overactivation of NMDA receptors can result in excitotoxicity, which is associated with various neurological and neurodegenerat...

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Detalles Bibliográficos
Autores principales: Steigerwald, Ruben, Chou, Tsung‐Han, Furukawa, Hiro, Wünsch, Bernhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9828697/
https://www.ncbi.nlm.nih.gov/pubmed/36169098
http://dx.doi.org/10.1002/cmdc.202200484

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9828697/
https://www.ncbi.nlm.nih.gov/pubmed/36169098
http://dx.doi.org/10.1002/cmdc.202200484

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