Application of a Screening‐Level Pollinator Risk Assessment Framework to Trisiloxane Polyether Surfactants

Regulatory requirements exist to assess the potential impacts of pesticides on insect pollinators, but “inert,” coformulants to pesticide formulations are not included in standard regulatory risk assessments. Some publications in the open literature have suggested that the agricultural uses of “inert” ingredients, including trisiloxane polyether surfactants, may result in adverse effects on pollinators. We conducted a screening‐level risk assessment to evaluate the potential risk to insect pollinators, using honey bees (Apis mellifera) as a surrogate, from exposure to three trisiloxane polyether surfactants based on agricultural application scenarios following the current US Environmental Protection Agency (USEPA) guidance. The exposure assessment included data from two sources: (1) use data reported in California's (USA) Pesticide Use Registry (PUR) database for all crops, and (2) an almond orchard residue study conducted using the three trisiloxane polyether surfactants. Honey bee laboratory studies with each of the trisiloxane polyether surfactants reported 50% lethal doses (LD50s) or no adverse effect levels, which were used as the effects inputs to BeeREX. The exposure and toxicity data were combined to estimate potential honey bee risk based on the determination of acute and chronic risk quotients (RQs) for larval and adult life stages. The RQs calculated using both the PUR use rates as well as the application rates and peak measured residues from the almond orchard residue study were below the USEPA acute and chronic levels of concern (acute, 0.4; chronic, 1.0). Based on these results, the use of these three trisiloxane polyether surfactants in agricultural use settings can be considered minimal risk to insect pollinators, and higher tier assessment is unnecessary for the characterization of risk. Environ Toxicol Chem 2022;41:3084–3094. © 2022 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.