Direct Synthesis of α‐Aryl‐α‐Trifluoromethyl Alcohols via Nickel Catalyzed Cross‐Electrophile Coupling

A nickel‐catalyzed reductive cross‐electrophile coupling between the redox‐active N‐trifluoroethoxyphthalimide and iodoarenes is documented. The protocol reproduces a formal arylation of trifluoroacetaldehyde under mild conditions in high yields (up to 88 %) and with large functional group tolerance...

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Detalles Bibliográficos
Autores principales: Lombardi, Lorenzo, Cerveri, Alessandro, Giovanelli, Riccardo, Castiñeira Reis, Marta, Silva López, Carlos, Bertuzzi, Giulio, Bandini, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9828748/
https://www.ncbi.nlm.nih.gov/pubmed/36161744
http://dx.doi.org/10.1002/anie.202211732

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9828748/
https://www.ncbi.nlm.nih.gov/pubmed/36161744
http://dx.doi.org/10.1002/anie.202211732

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