Microglia in motor neuron disease: Signaling evidence from last 10 years

Motor neuron disease (MND), including amyotrophic lateral sclerosis, spinal muscular atrophy and others, involved the upper or lower motor neurons selective loss, is characterized by neurodegeneration and neuroinflammation, in conjunction with microglia. We summarized that pathways and key mediators...

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Detalles Bibliográficos
Autores principales: Wang, Min‐Jia, Kang, Lu, Wang, Yao‐Zheng, Yang, Bi‐Ru, Zhang, Chun, Lu, Yu‐Feng, Kang, Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9828749/
https://www.ncbi.nlm.nih.gov/pubmed/36309345
http://dx.doi.org/10.1002/dneu.22905
Descripción
Sumario:Motor neuron disease (MND), including amyotrophic lateral sclerosis, spinal muscular atrophy and others, involved the upper or lower motor neurons selective loss, is characterized by neurodegeneration and neuroinflammation, in conjunction with microglia. We summarized that pathways and key mediators are associated with microglia, such as fractalkine signaling, purinergic signaling, NF‐κB signaling, p38 MAPK signaling, TREM2‐APOE signaling, ROCK signaling, C1q signaling, and Ion channel, which are involved in the activation, proliferation, and inflammation of microglia. This review aims to identify the microglia‐related molecular target and explore potential treatment strategies for MND based on that target.

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