Cargando…
The modulation of plasma levels of dopamine, serotonin, and brain-derived neurotrophic factor in response to variation in iron availability
BACKGROUND AND AIM: In the context of iron deficiency anemia, central dopamine, serotonin, and brain-derived neurotrophic factor (BDNF) are intensively investigated. However, peripheral isoforms are poorly investigated. This study aimed to investigate the modulation of plasma levels of dopamine, ser...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Mattioli 1885
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9828900/ https://www.ncbi.nlm.nih.gov/pubmed/36533769 http://dx.doi.org/10.23750/abm.v93i6.13276 |
_version_ | 1784867363408052224 |
---|---|
author | Bani-Ahmad, Mohammad A. Obeidat, Marya M. Ahmad, Marah H. Barqawi, Mousa |
author_facet | Bani-Ahmad, Mohammad A. Obeidat, Marya M. Ahmad, Marah H. Barqawi, Mousa |
author_sort | Bani-Ahmad, Mohammad A. |
collection | PubMed |
description | BACKGROUND AND AIM: In the context of iron deficiency anemia, central dopamine, serotonin, and brain-derived neurotrophic factor (BDNF) are intensively investigated. However, peripheral isoforms are poorly investigated. This study aimed to investigate the modulation of plasma levels of dopamine, serotonin, and BDNF among children with iron deficiency anemia. METHODS: A total of seventy-three iron-deficient (n=38) and iron-sufficient (n=35) children were included in the study. Twenty-nine subjects were showing clinical presentations and were diagnosed with iron deficiency anemia and forty-four were asymptomatic normal children. Plasma levels of dopamine, serotonin, and brain-derived neurotrophic factor were determined by enzyme-linked immunosorbent assay. RESULTS: As compared to corresponding levels among control subjects, Anemic subjects were having significantly higher plasma dopamine and lower plasma brain-derived neurotrophic factor levels. A significant linear and monotonic association of plasma dopamine and brain-derived neurotrophic factor with hemoglobin concentration (r=-0.520, P < 0.001 and ρ = 0.411, P = 0.001), respectively. Furthermore, there were significantly higher plasma serotonin levels among iron-deficient subjects with a significant inverse linear association with serum ferritin levels (r = -0.337, P = 0.005). CONCLUSIONS: Iron deficiency anemia is associated with the modulation of peripheral dopamine, serotonin, and brain-derived neurotrophic factor. Upregulation of dopamine and downregulation of brain-derived neurotrophic factor are correlated to the anemic status. The upregulation of plasma serotonin levels is iron-dependent and, probably, is attributed to the impairment of its metabolic fate. Further investigation is required to explore the pathophysiological and clinical association of these peripheral biomolecules in the context of iron deficiency anemia. (www.actabiomedica.it) |
format | Online Article Text |
id | pubmed-9828900 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Mattioli 1885 |
record_format | MEDLINE/PubMed |
spelling | pubmed-98289002023-01-19 The modulation of plasma levels of dopamine, serotonin, and brain-derived neurotrophic factor in response to variation in iron availability Bani-Ahmad, Mohammad A. Obeidat, Marya M. Ahmad, Marah H. Barqawi, Mousa Acta Biomed Original Article BACKGROUND AND AIM: In the context of iron deficiency anemia, central dopamine, serotonin, and brain-derived neurotrophic factor (BDNF) are intensively investigated. However, peripheral isoforms are poorly investigated. This study aimed to investigate the modulation of plasma levels of dopamine, serotonin, and BDNF among children with iron deficiency anemia. METHODS: A total of seventy-three iron-deficient (n=38) and iron-sufficient (n=35) children were included in the study. Twenty-nine subjects were showing clinical presentations and were diagnosed with iron deficiency anemia and forty-four were asymptomatic normal children. Plasma levels of dopamine, serotonin, and brain-derived neurotrophic factor were determined by enzyme-linked immunosorbent assay. RESULTS: As compared to corresponding levels among control subjects, Anemic subjects were having significantly higher plasma dopamine and lower plasma brain-derived neurotrophic factor levels. A significant linear and monotonic association of plasma dopamine and brain-derived neurotrophic factor with hemoglobin concentration (r=-0.520, P < 0.001 and ρ = 0.411, P = 0.001), respectively. Furthermore, there were significantly higher plasma serotonin levels among iron-deficient subjects with a significant inverse linear association with serum ferritin levels (r = -0.337, P = 0.005). CONCLUSIONS: Iron deficiency anemia is associated with the modulation of peripheral dopamine, serotonin, and brain-derived neurotrophic factor. Upregulation of dopamine and downregulation of brain-derived neurotrophic factor are correlated to the anemic status. The upregulation of plasma serotonin levels is iron-dependent and, probably, is attributed to the impairment of its metabolic fate. Further investigation is required to explore the pathophysiological and clinical association of these peripheral biomolecules in the context of iron deficiency anemia. (www.actabiomedica.it) Mattioli 1885 2022 2022-12-16 /pmc/articles/PMC9828900/ /pubmed/36533769 http://dx.doi.org/10.23750/abm.v93i6.13276 Text en Copyright: © 2022 ACTA BIO MEDICA SOCIETY OF MEDICINE AND NATURAL SCIENCES OF PARMA https://creativecommons.org/licenses/by-nc-sa/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License |
spellingShingle | Original Article Bani-Ahmad, Mohammad A. Obeidat, Marya M. Ahmad, Marah H. Barqawi, Mousa The modulation of plasma levels of dopamine, serotonin, and brain-derived neurotrophic factor in response to variation in iron availability |
title | The modulation of plasma levels of dopamine, serotonin, and brain-derived neurotrophic factor in response to variation in iron availability |
title_full | The modulation of plasma levels of dopamine, serotonin, and brain-derived neurotrophic factor in response to variation in iron availability |
title_fullStr | The modulation of plasma levels of dopamine, serotonin, and brain-derived neurotrophic factor in response to variation in iron availability |
title_full_unstemmed | The modulation of plasma levels of dopamine, serotonin, and brain-derived neurotrophic factor in response to variation in iron availability |
title_short | The modulation of plasma levels of dopamine, serotonin, and brain-derived neurotrophic factor in response to variation in iron availability |
title_sort | modulation of plasma levels of dopamine, serotonin, and brain-derived neurotrophic factor in response to variation in iron availability |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9828900/ https://www.ncbi.nlm.nih.gov/pubmed/36533769 http://dx.doi.org/10.23750/abm.v93i6.13276 |
work_keys_str_mv | AT baniahmadmohammada themodulationofplasmalevelsofdopamineserotoninandbrainderivedneurotrophicfactorinresponsetovariationinironavailability AT obeidatmaryam themodulationofplasmalevelsofdopamineserotoninandbrainderivedneurotrophicfactorinresponsetovariationinironavailability AT ahmadmarahh themodulationofplasmalevelsofdopamineserotoninandbrainderivedneurotrophicfactorinresponsetovariationinironavailability AT barqawimousa themodulationofplasmalevelsofdopamineserotoninandbrainderivedneurotrophicfactorinresponsetovariationinironavailability AT baniahmadmohammada modulationofplasmalevelsofdopamineserotoninandbrainderivedneurotrophicfactorinresponsetovariationinironavailability AT obeidatmaryam modulationofplasmalevelsofdopamineserotoninandbrainderivedneurotrophicfactorinresponsetovariationinironavailability AT ahmadmarahh modulationofplasmalevelsofdopamineserotoninandbrainderivedneurotrophicfactorinresponsetovariationinironavailability AT barqawimousa modulationofplasmalevelsofdopamineserotoninandbrainderivedneurotrophicfactorinresponsetovariationinironavailability |