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The modulation of plasma levels of dopamine, serotonin, and brain-derived neurotrophic factor in response to variation in iron availability

BACKGROUND AND AIM: In the context of iron deficiency anemia, central dopamine, serotonin, and brain-derived neurotrophic factor (BDNF) are intensively investigated. However, peripheral isoforms are poorly investigated. This study aimed to investigate the modulation of plasma levels of dopamine, ser...

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Autores principales: Bani-Ahmad, Mohammad A., Obeidat, Marya M., Ahmad, Marah H., Barqawi, Mousa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mattioli 1885 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9828900/
https://www.ncbi.nlm.nih.gov/pubmed/36533769
http://dx.doi.org/10.23750/abm.v93i6.13276
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author Bani-Ahmad, Mohammad A.
Obeidat, Marya M.
Ahmad, Marah H.
Barqawi, Mousa
author_facet Bani-Ahmad, Mohammad A.
Obeidat, Marya M.
Ahmad, Marah H.
Barqawi, Mousa
author_sort Bani-Ahmad, Mohammad A.
collection PubMed
description BACKGROUND AND AIM: In the context of iron deficiency anemia, central dopamine, serotonin, and brain-derived neurotrophic factor (BDNF) are intensively investigated. However, peripheral isoforms are poorly investigated. This study aimed to investigate the modulation of plasma levels of dopamine, serotonin, and BDNF among children with iron deficiency anemia. METHODS: A total of seventy-three iron-deficient (n=38) and iron-sufficient (n=35) children were included in the study. Twenty-nine subjects were showing clinical presentations and were diagnosed with iron deficiency anemia and forty-four were asymptomatic normal children. Plasma levels of dopamine, serotonin, and brain-derived neurotrophic factor were determined by enzyme-linked immunosorbent assay. RESULTS: As compared to corresponding levels among control subjects, Anemic subjects were having significantly higher plasma dopamine and lower plasma brain-derived neurotrophic factor levels. A significant linear and monotonic association of plasma dopamine and brain-derived neurotrophic factor with hemoglobin concentration (r=-0.520, P < 0.001 and ρ = 0.411, P = 0.001), respectively. Furthermore, there were significantly higher plasma serotonin levels among iron-deficient subjects with a significant inverse linear association with serum ferritin levels (r = -0.337, P = 0.005). CONCLUSIONS: Iron deficiency anemia is associated with the modulation of peripheral dopamine, serotonin, and brain-derived neurotrophic factor. Upregulation of dopamine and downregulation of brain-derived neurotrophic factor are correlated to the anemic status. The upregulation of plasma serotonin levels is iron-dependent and, probably, is attributed to the impairment of its metabolic fate. Further investigation is required to explore the pathophysiological and clinical association of these peripheral biomolecules in the context of iron deficiency anemia. (www.actabiomedica.it)
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spelling pubmed-98289002023-01-19 The modulation of plasma levels of dopamine, serotonin, and brain-derived neurotrophic factor in response to variation in iron availability Bani-Ahmad, Mohammad A. Obeidat, Marya M. Ahmad, Marah H. Barqawi, Mousa Acta Biomed Original Article BACKGROUND AND AIM: In the context of iron deficiency anemia, central dopamine, serotonin, and brain-derived neurotrophic factor (BDNF) are intensively investigated. However, peripheral isoforms are poorly investigated. This study aimed to investigate the modulation of plasma levels of dopamine, serotonin, and BDNF among children with iron deficiency anemia. METHODS: A total of seventy-three iron-deficient (n=38) and iron-sufficient (n=35) children were included in the study. Twenty-nine subjects were showing clinical presentations and were diagnosed with iron deficiency anemia and forty-four were asymptomatic normal children. Plasma levels of dopamine, serotonin, and brain-derived neurotrophic factor were determined by enzyme-linked immunosorbent assay. RESULTS: As compared to corresponding levels among control subjects, Anemic subjects were having significantly higher plasma dopamine and lower plasma brain-derived neurotrophic factor levels. A significant linear and monotonic association of plasma dopamine and brain-derived neurotrophic factor with hemoglobin concentration (r=-0.520, P < 0.001 and ρ = 0.411, P = 0.001), respectively. Furthermore, there were significantly higher plasma serotonin levels among iron-deficient subjects with a significant inverse linear association with serum ferritin levels (r = -0.337, P = 0.005). CONCLUSIONS: Iron deficiency anemia is associated with the modulation of peripheral dopamine, serotonin, and brain-derived neurotrophic factor. Upregulation of dopamine and downregulation of brain-derived neurotrophic factor are correlated to the anemic status. The upregulation of plasma serotonin levels is iron-dependent and, probably, is attributed to the impairment of its metabolic fate. Further investigation is required to explore the pathophysiological and clinical association of these peripheral biomolecules in the context of iron deficiency anemia. (www.actabiomedica.it) Mattioli 1885 2022 2022-12-16 /pmc/articles/PMC9828900/ /pubmed/36533769 http://dx.doi.org/10.23750/abm.v93i6.13276 Text en Copyright: © 2022 ACTA BIO MEDICA SOCIETY OF MEDICINE AND NATURAL SCIENCES OF PARMA https://creativecommons.org/licenses/by-nc-sa/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License
spellingShingle Original Article
Bani-Ahmad, Mohammad A.
Obeidat, Marya M.
Ahmad, Marah H.
Barqawi, Mousa
The modulation of plasma levels of dopamine, serotonin, and brain-derived neurotrophic factor in response to variation in iron availability
title The modulation of plasma levels of dopamine, serotonin, and brain-derived neurotrophic factor in response to variation in iron availability
title_full The modulation of plasma levels of dopamine, serotonin, and brain-derived neurotrophic factor in response to variation in iron availability
title_fullStr The modulation of plasma levels of dopamine, serotonin, and brain-derived neurotrophic factor in response to variation in iron availability
title_full_unstemmed The modulation of plasma levels of dopamine, serotonin, and brain-derived neurotrophic factor in response to variation in iron availability
title_short The modulation of plasma levels of dopamine, serotonin, and brain-derived neurotrophic factor in response to variation in iron availability
title_sort modulation of plasma levels of dopamine, serotonin, and brain-derived neurotrophic factor in response to variation in iron availability
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9828900/
https://www.ncbi.nlm.nih.gov/pubmed/36533769
http://dx.doi.org/10.23750/abm.v93i6.13276
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