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Medical uses for phenol in the urinary tract: A possible forgotten treatment (Review)

Phenol is a chemical compound that was first used medically as an antiseptic. At low concentrations, phenol exerts local anesthetic effects achieved through denervation; at high concentrations, it exerts a potent protein-denaturing effect that induces apoptosis. Phenol injection therapy has a long h...

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Autores principales: Sadahira, Takuya, Maruyama, Yuki, Watanabe, Toyohiko, Sekito, Takanori, Mitsui, Yosuke, Wada, Koichiro, Araki, Motoo, Watanabe, Masami
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9829081/
https://www.ncbi.nlm.nih.gov/pubmed/36698428
http://dx.doi.org/10.3892/mi.2021.13
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author Sadahira, Takuya
Maruyama, Yuki
Watanabe, Toyohiko
Sekito, Takanori
Mitsui, Yosuke
Wada, Koichiro
Araki, Motoo
Watanabe, Masami
author_facet Sadahira, Takuya
Maruyama, Yuki
Watanabe, Toyohiko
Sekito, Takanori
Mitsui, Yosuke
Wada, Koichiro
Araki, Motoo
Watanabe, Masami
author_sort Sadahira, Takuya
collection PubMed
description Phenol is a chemical compound that was first used medically as an antiseptic. At low concentrations, phenol exerts local anesthetic effects achieved through denervation; at high concentrations, it exerts a potent protein-denaturing effect that induces apoptosis. Phenol injection therapy has a long history of use in urology. It is reportedly effective for hemorrhagic cystitis, benign prostate hyperplasia, overactive bladder, hydrocele, bladder tumors, interstitial cystitis and other benign urologic diseases, and it is also used as a tool to decrease bleeding during prostate surgery. The present review article summarizes the medical applications of phenol in urological field. The articles available on the medical uses of phenol are primarily older and retrospective, involving small numbers of patients. In the absence of comparative studies with other treatments, it is impossible to determine the relative benefit of phenol. However, the treatment outcomes of phenol injection are fairly well-established. Phenol therapy may be an option for patients who are poor candidates for invasive treatment. Further studies are required, however, as are improvements in the injection technique to reduce the rate of complications.
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spelling pubmed-98290812023-01-24 Medical uses for phenol in the urinary tract: A possible forgotten treatment (Review) Sadahira, Takuya Maruyama, Yuki Watanabe, Toyohiko Sekito, Takanori Mitsui, Yosuke Wada, Koichiro Araki, Motoo Watanabe, Masami Med Int (Lond) Review Phenol is a chemical compound that was first used medically as an antiseptic. At low concentrations, phenol exerts local anesthetic effects achieved through denervation; at high concentrations, it exerts a potent protein-denaturing effect that induces apoptosis. Phenol injection therapy has a long history of use in urology. It is reportedly effective for hemorrhagic cystitis, benign prostate hyperplasia, overactive bladder, hydrocele, bladder tumors, interstitial cystitis and other benign urologic diseases, and it is also used as a tool to decrease bleeding during prostate surgery. The present review article summarizes the medical applications of phenol in urological field. The articles available on the medical uses of phenol are primarily older and retrospective, involving small numbers of patients. In the absence of comparative studies with other treatments, it is impossible to determine the relative benefit of phenol. However, the treatment outcomes of phenol injection are fairly well-established. Phenol therapy may be an option for patients who are poor candidates for invasive treatment. Further studies are required, however, as are improvements in the injection technique to reduce the rate of complications. D.A. Spandidos 2021-08-31 /pmc/articles/PMC9829081/ /pubmed/36698428 http://dx.doi.org/10.3892/mi.2021.13 Text en Copyright: © Sadahira et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.
spellingShingle Review
Sadahira, Takuya
Maruyama, Yuki
Watanabe, Toyohiko
Sekito, Takanori
Mitsui, Yosuke
Wada, Koichiro
Araki, Motoo
Watanabe, Masami
Medical uses for phenol in the urinary tract: A possible forgotten treatment (Review)
title Medical uses for phenol in the urinary tract: A possible forgotten treatment (Review)
title_full Medical uses for phenol in the urinary tract: A possible forgotten treatment (Review)
title_fullStr Medical uses for phenol in the urinary tract: A possible forgotten treatment (Review)
title_full_unstemmed Medical uses for phenol in the urinary tract: A possible forgotten treatment (Review)
title_short Medical uses for phenol in the urinary tract: A possible forgotten treatment (Review)
title_sort medical uses for phenol in the urinary tract: a possible forgotten treatment (review)
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9829081/
https://www.ncbi.nlm.nih.gov/pubmed/36698428
http://dx.doi.org/10.3892/mi.2021.13
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