Leveraging pleiotropy to discover and interpret GWAS results for sleep-associated traits

Genetic association studies of many heritable traits resulting from physiological testing often have modest sample sizes due to the cost and burden of the required phenotyping. This reduces statistical power and limits discovery of multiple genetic associations. We present a strategy to leverage ple...

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Detalles Bibliográficos
Autores principales: Chun, Sung, Akle, Sebastian, Teodosiadis, Athanasios, Cade, Brian E., Wang, Heming, Sofer, Tamar, Evans, Daniel S., Stone, Katie L., Gharib, Sina A., Mukherjee, Sutapa, Palmer, Lyle J., Hillman, David, Rotter, Jerome I., Hanis, Craig L., Stamatoyannopoulos, John A., Redline, Susan, Cotsapas, Chris, Sunyaev, Shamil R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9829185/
https://www.ncbi.nlm.nih.gov/pubmed/36574455
http://dx.doi.org/10.1371/journal.pgen.1010557

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