Cargando…

Upregulation of GLUT4 and PI3K, and downregulation of GSK3 mediate the anti-hyperglycemic effects of proanthocyanidins

Diabetes mellitus is the most common chronic metabolic disorder worldwide. The present study was designed to investigate the potential role of cinnamon bark extract oligomeric proanthocyanidins (OPCs) in controlling streptozotocin (STZ)-induced hyperglycemia and to clarify the underlying molecular m...

Descripción completa

Detalles Bibliográficos
Autores principales:	El-Ashmawy, Nahla E., Khedr, Eman G., Alfeky, Nehal H., Ibrahim, Amera O.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2022
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9829200/ https://www.ncbi.nlm.nih.gov/pubmed/36698506 http://dx.doi.org/10.3892/mi.2022.39

Ejemplares similares

Renoprotective Effects of Atorvastatin in Diabetic Mice: Downregulation of RhoA and Upregulation of Akt/GSK3
por: Bruder-Nascimento, Thiago, et al.
Publicado: (2016)

Amelioration of lithiatic injury to renal tissue by candesartan and sodium thiosulfate in a rat model of nephrolithiasis
por: El-Ashmawy, Nahla E., et al.
Publicado: (2021)

Trafficking regulator of GLUT4-1 (TRARG1) is a GSK3 substrate
por: Duan, Xiaowen, et al.
Publicado: (2022)

GSK3α phosphorylates dynamin-2 to promote GLUT4 endocytosis in muscle cells
por: Laiman, Jessica, et al.
Publicado: (2022)

Natural exosomes-like nanoparticles in mung bean sprouts possesses anti-diabetic effects via activation of PI3K/Akt/GLUT4/GSK-3β signaling pathway
por: He, Chengxun, et al.
Publicado: (2023)

SCUBE3 downregulation modulates hepatocellular carcinoma by inhibiting CCNE1 via TGFβ/PI3K/AKT/GSK3β pathway
por: Xu, Pan, et al.
Publicado: (2022)

Overstimulation can create health problems due to increases in PI3K/Akt/GSK3 insensitivity and GSK3 activity
por: Liu, Xunxian
Publicado: (2014)

Inhibition of PKC/MEK pathway suppresses β1-integrin and mitigates breast cancer cells proliferation
por: EL-Ashmawy, Nahla E., et al.
Publicado: (2021)

Blocking of The Prostaglandin E2 Receptor as a Therapeutic Strategy for Treatment of Breast Cancer: Promising Findings in a Mouse Model
por: EL-Ashmawy, Nahla E, et al.
Publicado: (2022)

Roles of PI3K/AKT/GSK3 Pathway Involved in Psychiatric Illnesses
por: Matsuda, Satoru, et al.
Publicado: (2019)

Does GSK-3 provide a shortcut for PI3K activation of Wnt signalling?
por: Voskas, Daniel, et al.
Publicado: (2010)

Dietary regulation of PI3K/AKT/GSK-3β pathway in Alzheimer’s disease
por: Kitagishi, Yasuko, et al.
Publicado: (2014)

Role of PI3K/Akt/GSK-3 Pathway in Emesis and Potential New Antiemetics
por: Zhong, W, et al.
Publicado: (2020)

The protective effect of proanthocyanidins on the psoriasis-like cell models via PI3K/AKT and HO-1
por: Zhao, Yangmeng, et al.
Publicado: (2022)

Expression of the glucose transporters GLUT1, GLUT3, GLUT4 and GLUT12 in human cancer cells
por: Barron, Carly, et al.
Publicado: (2012)

Requirement of GSK-3 for PUMA induction upon loss of pro-survival PI3K signaling
por: Schubert, Florian, et al.
Publicado: (2018)

Proanthocyanidin B2 inhibits proliferation and induces apoptosis of osteosarcoma cells by suppressing the PI3K/AKT pathway
por: Wu, Xinbo, et al.
Publicado: (2020)

Downregulation of GLUT3 impairs STYK1/NOK-mediated metabolic reprogramming and proliferation in NIH-3T3 cells
por: Shi, Weiye, et al.
Publicado: (2021)

Vaccination with Toxoplasma lysate antigen or its encapsulated niosomes form immunomodulates adjuvant-induced arthritis through JAK3 downregulation
por: Hassouna, Sally S., et al.
Publicado: (2023)

Carvacrol Attenuates Diabetic Cardiomyopathy by Modulating the PI3K/AKT/GLUT4 Pathway in Diabetic Mice
por: Hou, Ning, et al.
Publicado: (2019)

PI3K-GSK3 signaling regulates mammalian axon regeneration by inducing the expression of Smad1
por: Saijilafu,, et al.
Publicado: (2013)

Roles of PI3K/AKT/GSK3/mTOR Pathway in Cell Signaling of Mental Illnesses
por: Kitagishi, Yasuko, et al.
Publicado: (2012)

Berberine and Oligomeric Proanthocyanidins Exhibit Synergistic Efficacy Through Regulation of PI3K-Akt Signaling Pathway in Colorectal Cancer
por: Okuno, Keisuke, et al.
Publicado: (2022)

In vitro assessment of antitumor activities of the PI3K/mTOR inhibitor GSK2126458
por: Albawardi, Alia, et al.
Publicado: (2014)

Involvement of GLUT1 and GLUT3 in the growth of canine melanoma cells
por: Suwabe, Yoko, et al.
Publicado: (2021)

Dexamethasone Inhibits TRAIL-Induced Apoptosis through c-FLIP(L) Upregulation and DR5 Downregulation by GSK3β Activation in Cancer Cells
por: Jeon, Mi-Yeon, et al.
Publicado: (2020)

Expression of Glut-1, HIF-1α, PI3K and p-Akt in a case of ceruminous adenoma
por: Shen, Wan-Qin, et al.
Publicado: (2012)

Inhibition of GLUT-1 expression and the PI3K/Akt pathway to enhance the chemosensitivity of laryngeal carcinoma cells in vitro
por: Jiang, Tao, et al.
Publicado: (2018)

The downregulation of miR‐22 and miR‐372 may contribute to gestational diabetes mellitus through regulating glucose metabolism via the PI3K/AKT/GLUT4 pathway
por: Li, Wei, et al.
Publicado: (2022)

O-GlcNAcylation of GLI Transcription Factors in Hyperglycemic Conditions Augments Hedgehog activity: Hyperglycemic conditions upregulate GLI activity
por: Das, Shamik, et al.
Publicado: (2018)

Involvement of GSK-3β Phosphorylation Through PI3-K/Akt in Cerebral Ischemia-Induced Neurogenesis in Rats
por: Kisoh, Keishi, et al.
Publicado: (2016)

The Role of Insulin/IGF-1/PI3K/Akt/GSK3β Signaling in Parkinson's Disease Dementia
por: Yang, Liying, et al.
Publicado: (2018)

Convergent genomic and pharmacological evidence of PI3K/GSK3 signaling alterations in neurons from schizophrenia patients
por: Stertz, Laura, et al.
Publicado: (2020)

LY3023414 inhibits both osteogenesis and osteoclastogenesis through the PI3K/Akt/GSK3 signalling pathway
por: Chen, Xiaojun, et al.
Publicado: (2021)

Grape Seed Proanthocyanidin Extract Ameliorates Cardiac Remodelling After Myocardial Infarction Through PI3K/AKT Pathway in Mice
por: Ruan, Yongxue, et al.
Publicado: (2020)

Corrigendum: Berberine and Oligomeric Proanthocyanidins Exhibit Synergistic Efficacy Through Regulation of PI3K-Akt Signaling Pathway in Colorectal Cancer
por: Okuno, Keisuke, et al.
Publicado: (2022)

Glucose transporters GLUT1, GLUT3, and GLUT4 have different effects on osteoblast proliferation and metabolism
por: Arponen, Milja, et al.
Publicado: (2022)

Upregulation of PTEN in Glioma Cells by Cord Blood Mesenchymal Stem Cells Inhibits Migration via Downregulation of the PI3K/Akt Pathway
por: Dasari, Venkata Ramesh, et al.
Publicado: (2010)

miR-132-3p is a positive regulator of alpha-cell mass and is downregulated in obese hyperglycemic mice
por: Dusaulcy, Rodolphe, et al.
Publicado: (2019)

Expression of GLUT1 and GLUT3 Glucose Transporters in Endometrial and Breast Cancers
por: Krzeslak, Anna, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_pc416h59gl0kam6svcf84i6cvb