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Contradictory Effect of Notch1 and Notch2 on Phosphatase and Tensin Homolog and its Influence on Glioblastoma Angiogenesis
Many genes induce angiogenesis in tumors, and among them, Notch family genes have received particular attention due to their extensive network of connections with other genes active in this function. Suppression of angiogenic signaling has been studied in various cancers, confirming Notch's fun...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Salvia Medical Sciences Ltd
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9829453/ https://www.ncbi.nlm.nih.gov/pubmed/36643842 http://dx.doi.org/10.31661/gmj.v10i0.2091 |
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author | Shabani, Mostafa Javanshir, Hamid Taghvaei Bereimipour, Ahmad Sadrabadi, Amin Ebrahimi Jalili, Arsalan Nayernia, Karim |
author_facet | Shabani, Mostafa Javanshir, Hamid Taghvaei Bereimipour, Ahmad Sadrabadi, Amin Ebrahimi Jalili, Arsalan Nayernia, Karim |
author_sort | Shabani, Mostafa |
collection | PubMed |
description | Many genes induce angiogenesis in tumors, and among them, Notch family genes have received particular attention due to their extensive network of connections with other genes active in this function. Suppression of angiogenic signaling has been studied in various cancers, confirming Notch's fundamental and extensive role. According to studies, four Notch genes work independently with many genes such as vascular endothelial growth factor, phosphatase and tensin homolog, Phosphoinositide 3-kinase/Akt, and matrix metalloproteinases, and so many other genes, as well as proteins (such as hypoxia-inducible factor-1 alpha) significantly affect tumor angiogenesis. Notch1 regular activity in a healthy person causes angiogenesis in body tissues, controlled by normal Notch2 activity. However, in many cases of glioblastoma, whether on patients or tumor xenografts or in vivo models, a mutation in one of these two essential genes or at least one of the genes and proteins that affected by them can cause better angiogenesis in hypoxic conditions and lead to become an invasive tumor. In this review, we examined the contrasting activity of Notch1 and Notch2 and the signaling cascade that each generates in the angiogenesis of glioblastoma, the most invasive cancer of the central nervous system. |
format | Online Article Text |
id | pubmed-9829453 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Salvia Medical Sciences Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-98294532023-01-12 Contradictory Effect of Notch1 and Notch2 on Phosphatase and Tensin Homolog and its Influence on Glioblastoma Angiogenesis Shabani, Mostafa Javanshir, Hamid Taghvaei Bereimipour, Ahmad Sadrabadi, Amin Ebrahimi Jalili, Arsalan Nayernia, Karim Galen Med J Review Article Many genes induce angiogenesis in tumors, and among them, Notch family genes have received particular attention due to their extensive network of connections with other genes active in this function. Suppression of angiogenic signaling has been studied in various cancers, confirming Notch's fundamental and extensive role. According to studies, four Notch genes work independently with many genes such as vascular endothelial growth factor, phosphatase and tensin homolog, Phosphoinositide 3-kinase/Akt, and matrix metalloproteinases, and so many other genes, as well as proteins (such as hypoxia-inducible factor-1 alpha) significantly affect tumor angiogenesis. Notch1 regular activity in a healthy person causes angiogenesis in body tissues, controlled by normal Notch2 activity. However, in many cases of glioblastoma, whether on patients or tumor xenografts or in vivo models, a mutation in one of these two essential genes or at least one of the genes and proteins that affected by them can cause better angiogenesis in hypoxic conditions and lead to become an invasive tumor. In this review, we examined the contrasting activity of Notch1 and Notch2 and the signaling cascade that each generates in the angiogenesis of glioblastoma, the most invasive cancer of the central nervous system. Salvia Medical Sciences Ltd 2021-09-28 /pmc/articles/PMC9829453/ /pubmed/36643842 http://dx.doi.org/10.31661/gmj.v10i0.2091 Text en Copyright© 2021, Galen Medical Journal. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ) |
spellingShingle | Review Article Shabani, Mostafa Javanshir, Hamid Taghvaei Bereimipour, Ahmad Sadrabadi, Amin Ebrahimi Jalili, Arsalan Nayernia, Karim Contradictory Effect of Notch1 and Notch2 on Phosphatase and Tensin Homolog and its Influence on Glioblastoma Angiogenesis |
title | Contradictory Effect of Notch1 and Notch2 on Phosphatase and Tensin Homolog and its Influence on Glioblastoma Angiogenesis |
title_full | Contradictory Effect of Notch1 and Notch2 on Phosphatase and Tensin Homolog and its Influence on Glioblastoma Angiogenesis |
title_fullStr | Contradictory Effect of Notch1 and Notch2 on Phosphatase and Tensin Homolog and its Influence on Glioblastoma Angiogenesis |
title_full_unstemmed | Contradictory Effect of Notch1 and Notch2 on Phosphatase and Tensin Homolog and its Influence on Glioblastoma Angiogenesis |
title_short | Contradictory Effect of Notch1 and Notch2 on Phosphatase and Tensin Homolog and its Influence on Glioblastoma Angiogenesis |
title_sort | contradictory effect of notch1 and notch2 on phosphatase and tensin homolog and its influence on glioblastoma angiogenesis |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9829453/ https://www.ncbi.nlm.nih.gov/pubmed/36643842 http://dx.doi.org/10.31661/gmj.v10i0.2091 |
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