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Adult-Onset Type 1 Diabetes Development Following COVID-19 mRNA Vaccination

During the coronavirus disease 2019 (COVID-19) pandemic, COVID-19 vaccination-induced hyperglycemia and related complications have been reported. However, there have been few reports of type 1 diabetes triggered by COVID-19 vaccines in subjects without diabetes. Here, we report the case of a 56-year...

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Autores principales: Moon, Hyeyeon, Suh, Sunghwan, Park, Mi Kyoung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9829515/
https://www.ncbi.nlm.nih.gov/pubmed/36625174
http://dx.doi.org/10.3346/jkms.2023.38.e12
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author Moon, Hyeyeon
Suh, Sunghwan
Park, Mi Kyoung
author_facet Moon, Hyeyeon
Suh, Sunghwan
Park, Mi Kyoung
author_sort Moon, Hyeyeon
collection PubMed
description During the coronavirus disease 2019 (COVID-19) pandemic, COVID-19 vaccination-induced hyperglycemia and related complications have been reported. However, there have been few reports of type 1 diabetes triggered by COVID-19 vaccines in subjects without diabetes. Here, we report the case of a 56-year-old female patient who developed hyperglycemia after the second dose of COVID-19 mRNA-based vaccination without a prior history of diabetes. She visited our hospital with uncontrolled hyperglycemia despite administration of oral hyperglycemic agents. Her initial glycated hemoglobin level was high (11.0%), and fasting serum C-peptide level was normal. The fasting serum C-peptide level decreased to 0.269 ng/mL 5 days after admission, and the anti-glutamic acid decarboxylase antibody was positive. The patient was discharged in stable condition with insulin treatment. To our knowledge, this is the first case of the development of type 1 diabetes without diabetic ketoacidosis after mRNA-based COVID-19 vaccination, and is the oldest case of type 1 diabetes development under such circumstances.
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spelling pubmed-98295152023-01-19 Adult-Onset Type 1 Diabetes Development Following COVID-19 mRNA Vaccination Moon, Hyeyeon Suh, Sunghwan Park, Mi Kyoung J Korean Med Sci Case Report During the coronavirus disease 2019 (COVID-19) pandemic, COVID-19 vaccination-induced hyperglycemia and related complications have been reported. However, there have been few reports of type 1 diabetes triggered by COVID-19 vaccines in subjects without diabetes. Here, we report the case of a 56-year-old female patient who developed hyperglycemia after the second dose of COVID-19 mRNA-based vaccination without a prior history of diabetes. She visited our hospital with uncontrolled hyperglycemia despite administration of oral hyperglycemic agents. Her initial glycated hemoglobin level was high (11.0%), and fasting serum C-peptide level was normal. The fasting serum C-peptide level decreased to 0.269 ng/mL 5 days after admission, and the anti-glutamic acid decarboxylase antibody was positive. The patient was discharged in stable condition with insulin treatment. To our knowledge, this is the first case of the development of type 1 diabetes without diabetic ketoacidosis after mRNA-based COVID-19 vaccination, and is the oldest case of type 1 diabetes development under such circumstances. The Korean Academy of Medical Sciences 2022-12-08 /pmc/articles/PMC9829515/ /pubmed/36625174 http://dx.doi.org/10.3346/jkms.2023.38.e12 Text en © 2023 The Korean Academy of Medical Sciences. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Moon, Hyeyeon
Suh, Sunghwan
Park, Mi Kyoung
Adult-Onset Type 1 Diabetes Development Following COVID-19 mRNA Vaccination
title Adult-Onset Type 1 Diabetes Development Following COVID-19 mRNA Vaccination
title_full Adult-Onset Type 1 Diabetes Development Following COVID-19 mRNA Vaccination
title_fullStr Adult-Onset Type 1 Diabetes Development Following COVID-19 mRNA Vaccination
title_full_unstemmed Adult-Onset Type 1 Diabetes Development Following COVID-19 mRNA Vaccination
title_short Adult-Onset Type 1 Diabetes Development Following COVID-19 mRNA Vaccination
title_sort adult-onset type 1 diabetes development following covid-19 mrna vaccination
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9829515/
https://www.ncbi.nlm.nih.gov/pubmed/36625174
http://dx.doi.org/10.3346/jkms.2023.38.e12
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