Microglia ferroptosis is regulated by SEC24B and contributes to neurodegeneration

Iron dysregulation has been implicated in multiple neurodegenerative diseases, including Parkinson’s disease (PD). Iron-loaded microglia are frequently found in affected brain regions, but how iron accumulation influences microglia physiology and contributes to neurodegeneration is poorly understood...

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Detalles Bibliográficos
Autores principales: Ryan, Sean K., Zelic, Matija, Han, Yingnan, Teeple, Erin, Chen, Luoman, Sadeghi, Mahdiar, Shankara, Srinivas, Guo, Lilu, Li, Cong, Pontarelli, Fabrizio, Jensen, Elizabeth H., Comer, Ashley L., Kumar, Dinesh, Zhang, Mindy, Gans, Joseph, Zhang, Bailin, Proto, Jonathan D., Saleh, Jacqueline, Dodge, James C., Savova, Virginia, Rajpal, Deepak, Ofengeim, Dimitry, Hammond, Timothy R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9829540/
https://www.ncbi.nlm.nih.gov/pubmed/36536241
http://dx.doi.org/10.1038/s41593-022-01221-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9829540/
https://www.ncbi.nlm.nih.gov/pubmed/36536241
http://dx.doi.org/10.1038/s41593-022-01221-3

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