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Hippocampal spatial representations exhibit a hyperbolic geometry that expands with experience

Daily experience suggests that we perceive distances near us linearly. However, the actual geometry of spatial representation in the brain is unknown. Here we report that neurons in the CA1 region of rat hippocampus that mediate spatial perception represent space according to a non-linear hyperbolic...

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Autores principales: Zhang, Huanqiu, Rich, P. Dylan, Lee, Albert K., Sharpee, Tatyana O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9829541/
https://www.ncbi.nlm.nih.gov/pubmed/36581729
http://dx.doi.org/10.1038/s41593-022-01212-4
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author Zhang, Huanqiu
Rich, P. Dylan
Lee, Albert K.
Sharpee, Tatyana O.
author_facet Zhang, Huanqiu
Rich, P. Dylan
Lee, Albert K.
Sharpee, Tatyana O.
author_sort Zhang, Huanqiu
collection PubMed
description Daily experience suggests that we perceive distances near us linearly. However, the actual geometry of spatial representation in the brain is unknown. Here we report that neurons in the CA1 region of rat hippocampus that mediate spatial perception represent space according to a non-linear hyperbolic geometry. This geometry uses an exponential scale and yields greater positional information than a linear scale. We found that the size of the representation matches the optimal predictions for the number of CA1 neurons. The representations also dynamically expanded proportional to the logarithm of time that the animal spent exploring the environment, in correspondence with the maximal mutual information that can be received. The dynamic changes tracked even small variations due to changes in the running speed of the animal. These results demonstrate how neural circuits achieve efficient representations using dynamic hyperbolic geometry.
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spelling pubmed-98295412023-01-11 Hippocampal spatial representations exhibit a hyperbolic geometry that expands with experience Zhang, Huanqiu Rich, P. Dylan Lee, Albert K. Sharpee, Tatyana O. Nat Neurosci Article Daily experience suggests that we perceive distances near us linearly. However, the actual geometry of spatial representation in the brain is unknown. Here we report that neurons in the CA1 region of rat hippocampus that mediate spatial perception represent space according to a non-linear hyperbolic geometry. This geometry uses an exponential scale and yields greater positional information than a linear scale. We found that the size of the representation matches the optimal predictions for the number of CA1 neurons. The representations also dynamically expanded proportional to the logarithm of time that the animal spent exploring the environment, in correspondence with the maximal mutual information that can be received. The dynamic changes tracked even small variations due to changes in the running speed of the animal. These results demonstrate how neural circuits achieve efficient representations using dynamic hyperbolic geometry. Nature Publishing Group US 2022-12-29 2023 /pmc/articles/PMC9829541/ /pubmed/36581729 http://dx.doi.org/10.1038/s41593-022-01212-4 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Zhang, Huanqiu
Rich, P. Dylan
Lee, Albert K.
Sharpee, Tatyana O.
Hippocampal spatial representations exhibit a hyperbolic geometry that expands with experience
title Hippocampal spatial representations exhibit a hyperbolic geometry that expands with experience
title_full Hippocampal spatial representations exhibit a hyperbolic geometry that expands with experience
title_fullStr Hippocampal spatial representations exhibit a hyperbolic geometry that expands with experience
title_full_unstemmed Hippocampal spatial representations exhibit a hyperbolic geometry that expands with experience
title_short Hippocampal spatial representations exhibit a hyperbolic geometry that expands with experience
title_sort hippocampal spatial representations exhibit a hyperbolic geometry that expands with experience
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9829541/
https://www.ncbi.nlm.nih.gov/pubmed/36581729
http://dx.doi.org/10.1038/s41593-022-01212-4
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