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Health-related quality of life of children born very preterm: a multinational European cohort study

PURPOSE: This study aims to (1) describe the health-related quality of life (HRQoL) outcomes experienced by children born very preterm (28–31 weeks’ gestation) and extremely preterm (< 28 weeks’ gestation) at five years of age and (2) explore the mediation effects of bronchopulmonary dysplasia (B...

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Autores principales: Kim, Sung Wook, Andronis, Lazaros, Seppänen, Anna-Veera, Aubert, Adrien M., Barros, Henrique, Draper, Elizabeth S., Sentenac, Mariane, Zeitlin, Jennifer, Petrou, Stavros
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9829588/
https://www.ncbi.nlm.nih.gov/pubmed/35976599
http://dx.doi.org/10.1007/s11136-022-03217-9
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author Kim, Sung Wook
Andronis, Lazaros
Seppänen, Anna-Veera
Aubert, Adrien M.
Barros, Henrique
Draper, Elizabeth S.
Sentenac, Mariane
Zeitlin, Jennifer
Petrou, Stavros
author_facet Kim, Sung Wook
Andronis, Lazaros
Seppänen, Anna-Veera
Aubert, Adrien M.
Barros, Henrique
Draper, Elizabeth S.
Sentenac, Mariane
Zeitlin, Jennifer
Petrou, Stavros
author_sort Kim, Sung Wook
collection PubMed
description PURPOSE: This study aims to (1) describe the health-related quality of life (HRQoL) outcomes experienced by children born very preterm (28–31 weeks’ gestation) and extremely preterm (< 28 weeks’ gestation) at five years of age and (2) explore the mediation effects of bronchopulmonary dysplasia (BPD) and severe non-respiratory neonatal morbidity on those outcomes. METHODS: This investigation was based on data for 3687 children born at < 32 weeks’ gestation that contributed to the EPICE and SHIPS studies conducted in 19 regions across 11 European countries. Descriptive statistics and multi-level ordinary linear squares (OLS) regression were used to explore the association between perinatal and sociodemographic characteristics and PedsQL(™) GCS scores. A mediation analysis that applied generalised structural equation modelling explored the association between potential mediators and PedsQL(™) GCS scores. RESULTS: The multi-level OLS regression (fully adjusted model) revealed that birth at < 26 weeks’ gestation, BPD status and experience of severe non-respiratory morbidity were associated with mean decrements in the total PedsQL(™) GCS score of 0.35, 3.71 and 5.87, respectively. The mediation analysis revealed that the indirect effects of BPD and severe non-respiratory morbidity on the total PedsQL(™) GCS score translated into decrements of 1.73 and 17.56, respectively, at < 26 weeks’ gestation; 0.99 and 10.95, respectively, at 26–27 weeks’ gestation; and 0.34 and 4.80, respectively, at 28–29 weeks’ gestation (referent: birth at 30–31 weeks’ gestation). CONCLUSION: The findings suggest that HRQoL is particularly impaired by extremely preterm birth and the concomitant complications of preterm birth such as BPD and severe non-respiratory morbidity. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11136-022-03217-9.
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spelling pubmed-98295882023-01-11 Health-related quality of life of children born very preterm: a multinational European cohort study Kim, Sung Wook Andronis, Lazaros Seppänen, Anna-Veera Aubert, Adrien M. Barros, Henrique Draper, Elizabeth S. Sentenac, Mariane Zeitlin, Jennifer Petrou, Stavros Qual Life Res Article PURPOSE: This study aims to (1) describe the health-related quality of life (HRQoL) outcomes experienced by children born very preterm (28–31 weeks’ gestation) and extremely preterm (< 28 weeks’ gestation) at five years of age and (2) explore the mediation effects of bronchopulmonary dysplasia (BPD) and severe non-respiratory neonatal morbidity on those outcomes. METHODS: This investigation was based on data for 3687 children born at < 32 weeks’ gestation that contributed to the EPICE and SHIPS studies conducted in 19 regions across 11 European countries. Descriptive statistics and multi-level ordinary linear squares (OLS) regression were used to explore the association between perinatal and sociodemographic characteristics and PedsQL(™) GCS scores. A mediation analysis that applied generalised structural equation modelling explored the association between potential mediators and PedsQL(™) GCS scores. RESULTS: The multi-level OLS regression (fully adjusted model) revealed that birth at < 26 weeks’ gestation, BPD status and experience of severe non-respiratory morbidity were associated with mean decrements in the total PedsQL(™) GCS score of 0.35, 3.71 and 5.87, respectively. The mediation analysis revealed that the indirect effects of BPD and severe non-respiratory morbidity on the total PedsQL(™) GCS score translated into decrements of 1.73 and 17.56, respectively, at < 26 weeks’ gestation; 0.99 and 10.95, respectively, at 26–27 weeks’ gestation; and 0.34 and 4.80, respectively, at 28–29 weeks’ gestation (referent: birth at 30–31 weeks’ gestation). CONCLUSION: The findings suggest that HRQoL is particularly impaired by extremely preterm birth and the concomitant complications of preterm birth such as BPD and severe non-respiratory morbidity. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11136-022-03217-9. Springer International Publishing 2022-08-17 2023 /pmc/articles/PMC9829588/ /pubmed/35976599 http://dx.doi.org/10.1007/s11136-022-03217-9 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Kim, Sung Wook
Andronis, Lazaros
Seppänen, Anna-Veera
Aubert, Adrien M.
Barros, Henrique
Draper, Elizabeth S.
Sentenac, Mariane
Zeitlin, Jennifer
Petrou, Stavros
Health-related quality of life of children born very preterm: a multinational European cohort study
title Health-related quality of life of children born very preterm: a multinational European cohort study
title_full Health-related quality of life of children born very preterm: a multinational European cohort study
title_fullStr Health-related quality of life of children born very preterm: a multinational European cohort study
title_full_unstemmed Health-related quality of life of children born very preterm: a multinational European cohort study
title_short Health-related quality of life of children born very preterm: a multinational European cohort study
title_sort health-related quality of life of children born very preterm: a multinational european cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9829588/
https://www.ncbi.nlm.nih.gov/pubmed/35976599
http://dx.doi.org/10.1007/s11136-022-03217-9
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