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Impaired muscle stem cell function and abnormal myogenesis in acquired myopathies
Skeletal muscle possesses a high plasticity and a remarkable regenerative capacity that relies mainly on muscle stem cells (MuSCs). Molecular and cellular components of the MuSC niche, such as immune cells, play key roles to coordinate MuSC function and to orchestrate muscle regeneration. An abnorma...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Portland Press Ltd.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9829652/ https://www.ncbi.nlm.nih.gov/pubmed/36538023 http://dx.doi.org/10.1042/BSR20220284 |
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author | Deprez, Alyson Orfi, Zakaria Rieger, Lupann Dumont, Nicolas Alexandre |
author_facet | Deprez, Alyson Orfi, Zakaria Rieger, Lupann Dumont, Nicolas Alexandre |
author_sort | Deprez, Alyson |
collection | PubMed |
description | Skeletal muscle possesses a high plasticity and a remarkable regenerative capacity that relies mainly on muscle stem cells (MuSCs). Molecular and cellular components of the MuSC niche, such as immune cells, play key roles to coordinate MuSC function and to orchestrate muscle regeneration. An abnormal infiltration of immune cells and/or imbalance of pro- and anti-inflammatory cytokines could lead to MuSC dysfunctions that could have long lasting effects on muscle function. Different genetic variants were shown to cause muscular dystrophies that intrinsically compromise MuSC function and/or disturb their microenvironment leading to impaired muscle regeneration that contributes to disease progression. Alternatively, many acquired myopathies caused by comorbidities (e.g., cardiopulmonary or kidney diseases), chronic inflammation/infection, or side effects of different drugs can also perturb MuSC function and their microenvironment. The goal of this review is to comprehensively summarize the current knowledge on acquired myopathies and their impact on MuSC function. We further describe potential therapeutic strategies to restore MuSC regenerative capacity. |
format | Online Article Text |
id | pubmed-9829652 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Portland Press Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-98296522023-01-19 Impaired muscle stem cell function and abnormal myogenesis in acquired myopathies Deprez, Alyson Orfi, Zakaria Rieger, Lupann Dumont, Nicolas Alexandre Biosci Rep Stem Cells Skeletal muscle possesses a high plasticity and a remarkable regenerative capacity that relies mainly on muscle stem cells (MuSCs). Molecular and cellular components of the MuSC niche, such as immune cells, play key roles to coordinate MuSC function and to orchestrate muscle regeneration. An abnormal infiltration of immune cells and/or imbalance of pro- and anti-inflammatory cytokines could lead to MuSC dysfunctions that could have long lasting effects on muscle function. Different genetic variants were shown to cause muscular dystrophies that intrinsically compromise MuSC function and/or disturb their microenvironment leading to impaired muscle regeneration that contributes to disease progression. Alternatively, many acquired myopathies caused by comorbidities (e.g., cardiopulmonary or kidney diseases), chronic inflammation/infection, or side effects of different drugs can also perturb MuSC function and their microenvironment. The goal of this review is to comprehensively summarize the current knowledge on acquired myopathies and their impact on MuSC function. We further describe potential therapeutic strategies to restore MuSC regenerative capacity. Portland Press Ltd. 2023-01-06 /pmc/articles/PMC9829652/ /pubmed/36538023 http://dx.doi.org/10.1042/BSR20220284 Text en © 2023 The Author(s). https://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Stem Cells Deprez, Alyson Orfi, Zakaria Rieger, Lupann Dumont, Nicolas Alexandre Impaired muscle stem cell function and abnormal myogenesis in acquired myopathies |
title | Impaired muscle stem cell function and abnormal myogenesis in acquired myopathies |
title_full | Impaired muscle stem cell function and abnormal myogenesis in acquired myopathies |
title_fullStr | Impaired muscle stem cell function and abnormal myogenesis in acquired myopathies |
title_full_unstemmed | Impaired muscle stem cell function and abnormal myogenesis in acquired myopathies |
title_short | Impaired muscle stem cell function and abnormal myogenesis in acquired myopathies |
title_sort | impaired muscle stem cell function and abnormal myogenesis in acquired myopathies |
topic | Stem Cells |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9829652/ https://www.ncbi.nlm.nih.gov/pubmed/36538023 http://dx.doi.org/10.1042/BSR20220284 |
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