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Impaired muscle stem cell function and abnormal myogenesis in acquired myopathies

Skeletal muscle possesses a high plasticity and a remarkable regenerative capacity that relies mainly on muscle stem cells (MuSCs). Molecular and cellular components of the MuSC niche, such as immune cells, play key roles to coordinate MuSC function and to orchestrate muscle regeneration. An abnorma...

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Autores principales: Deprez, Alyson, Orfi, Zakaria, Rieger, Lupann, Dumont, Nicolas Alexandre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9829652/
https://www.ncbi.nlm.nih.gov/pubmed/36538023
http://dx.doi.org/10.1042/BSR20220284
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author Deprez, Alyson
Orfi, Zakaria
Rieger, Lupann
Dumont, Nicolas Alexandre
author_facet Deprez, Alyson
Orfi, Zakaria
Rieger, Lupann
Dumont, Nicolas Alexandre
author_sort Deprez, Alyson
collection PubMed
description Skeletal muscle possesses a high plasticity and a remarkable regenerative capacity that relies mainly on muscle stem cells (MuSCs). Molecular and cellular components of the MuSC niche, such as immune cells, play key roles to coordinate MuSC function and to orchestrate muscle regeneration. An abnormal infiltration of immune cells and/or imbalance of pro- and anti-inflammatory cytokines could lead to MuSC dysfunctions that could have long lasting effects on muscle function. Different genetic variants were shown to cause muscular dystrophies that intrinsically compromise MuSC function and/or disturb their microenvironment leading to impaired muscle regeneration that contributes to disease progression. Alternatively, many acquired myopathies caused by comorbidities (e.g., cardiopulmonary or kidney diseases), chronic inflammation/infection, or side effects of different drugs can also perturb MuSC function and their microenvironment. The goal of this review is to comprehensively summarize the current knowledge on acquired myopathies and their impact on MuSC function. We further describe potential therapeutic strategies to restore MuSC regenerative capacity.
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spelling pubmed-98296522023-01-19 Impaired muscle stem cell function and abnormal myogenesis in acquired myopathies Deprez, Alyson Orfi, Zakaria Rieger, Lupann Dumont, Nicolas Alexandre Biosci Rep Stem Cells Skeletal muscle possesses a high plasticity and a remarkable regenerative capacity that relies mainly on muscle stem cells (MuSCs). Molecular and cellular components of the MuSC niche, such as immune cells, play key roles to coordinate MuSC function and to orchestrate muscle regeneration. An abnormal infiltration of immune cells and/or imbalance of pro- and anti-inflammatory cytokines could lead to MuSC dysfunctions that could have long lasting effects on muscle function. Different genetic variants were shown to cause muscular dystrophies that intrinsically compromise MuSC function and/or disturb their microenvironment leading to impaired muscle regeneration that contributes to disease progression. Alternatively, many acquired myopathies caused by comorbidities (e.g., cardiopulmonary or kidney diseases), chronic inflammation/infection, or side effects of different drugs can also perturb MuSC function and their microenvironment. The goal of this review is to comprehensively summarize the current knowledge on acquired myopathies and their impact on MuSC function. We further describe potential therapeutic strategies to restore MuSC regenerative capacity. Portland Press Ltd. 2023-01-06 /pmc/articles/PMC9829652/ /pubmed/36538023 http://dx.doi.org/10.1042/BSR20220284 Text en © 2023 The Author(s). https://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Stem Cells
Deprez, Alyson
Orfi, Zakaria
Rieger, Lupann
Dumont, Nicolas Alexandre
Impaired muscle stem cell function and abnormal myogenesis in acquired myopathies
title Impaired muscle stem cell function and abnormal myogenesis in acquired myopathies
title_full Impaired muscle stem cell function and abnormal myogenesis in acquired myopathies
title_fullStr Impaired muscle stem cell function and abnormal myogenesis in acquired myopathies
title_full_unstemmed Impaired muscle stem cell function and abnormal myogenesis in acquired myopathies
title_short Impaired muscle stem cell function and abnormal myogenesis in acquired myopathies
title_sort impaired muscle stem cell function and abnormal myogenesis in acquired myopathies
topic Stem Cells
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9829652/
https://www.ncbi.nlm.nih.gov/pubmed/36538023
http://dx.doi.org/10.1042/BSR20220284
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