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Prion protein amino acid sequence influences formation of authentic synthetic PrP(Sc)

Synthetic prions, generated de novo from minimal, non-infectious components, cause bona fide prion disease in animals. Transmission of synthetic prions to hosts expressing syngeneic PrP(C) results in extended, variable incubation periods and incomplete attack rates. In contrast, murine synthetic pri...

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Detalles Bibliográficos
Autores principales:	Block, Alyssa J., York, Taylor C., Benedict, Romilly, Ma, Jiyan, Bartz, Jason C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9829857/ https://www.ncbi.nlm.nih.gov/pubmed/36624174 http://dx.doi.org/10.1038/s41598-022-26300-0

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