The CDK inhibitor AT7519 inhibits human glioblastoma cell growth by inducing apoptosis, pyroptosis and cell cycle arrest

Glioblastoma multiforme (GBM) is the most lethal primary brain tumor with a poor median survival of less than 15 months. However, clinical strategies and effective therapies are limited. Here, we found that the second-generation small molecule multi-CDK inhibitor AT7519 is a potential drug for GBM t...

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Detalles Bibliográficos
Autores principales: Zhao, Wenpeng, Zhang, Liang, Zhang, Yaya, Jiang, Zhengye, Lu, Hanwen, Xie, Yuanyuan, Han, Wanhong, Zhao, Wentao, He, Jiawei, Shi, Zhongjie, Yang, Huiying, Chen, Junjie, Chen, Sifang, Li, Zhangyu, Mao, Jianyao, Zhou, Liwei, Gao, Xin, Li, Wenhua, Tan, Guowei, Zhang, Bingchang, Wang, Zhanxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9829897/
https://www.ncbi.nlm.nih.gov/pubmed/36624090
http://dx.doi.org/10.1038/s41419-022-05528-8

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