Apremilast prevents blistering in human epidermis and stabilizes keratinocyte adhesion in pemphigus

Pemphigus vulgaris is a life-threatening blistering skin disease caused by autoantibodies destabilizing desmosomal adhesion. Current therapies focus on suppression of autoantibody formation and thus treatments directly stabilizing keratinocyte adhesion would fulfill an unmet medical need. We here de...

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Detalles Bibliográficos
Autores principales: Sigmund, Anna M., Winkler, Markus, Engelmayer, Sophia, Kugelmann, Daniela, Egu, Desalegn T., Steinert, Letyfee S., Fuchs, Michael, Hiermaier, Matthias, Radeva, Mariya Y., Bayerbach, Franziska C., Butz, Elisabeth, Kotschi, Stefan, Hudemann, Christoph, Hertl, Michael, Yeruva, Sunil, Schmidt, Enno, Yazdi, Amir S., Ghoreschi, Kamran, Vielmuth, Franziska, Waschke, Jens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9829900/
https://www.ncbi.nlm.nih.gov/pubmed/36624106
http://dx.doi.org/10.1038/s41467-022-35741-0

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