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Increased Risk of Anemia in Patients with Asthma
PURPOSE: Asthma can cause a systemic inflammatory response, and anemia of chronic disease (ACD) is known to be caused by other disorders with a chronic inflammatory state. However, it is unclear whether the incidence of anemia is increased in patients with asthma. The objective of this study was to...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Dove
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9830059/ https://www.ncbi.nlm.nih.gov/pubmed/36636733 http://dx.doi.org/10.2147/CLEP.S394717 |
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author | Rhew, Kiyon Choi, Jisu Kim, Kyungim Choi, Kyung Hee Lee, So-Hee Park, Heung-Woo |
author_facet | Rhew, Kiyon Choi, Jisu Kim, Kyungim Choi, Kyung Hee Lee, So-Hee Park, Heung-Woo |
author_sort | Rhew, Kiyon |
collection | PubMed |
description | PURPOSE: Asthma can cause a systemic inflammatory response, and anemia of chronic disease (ACD) is known to be caused by other disorders with a chronic inflammatory state. However, it is unclear whether the incidence of anemia is increased in patients with asthma. The objective of this study was to compare the incidence of anemia in patients with asthma and healthy adults. PATIENTS AND METHODS: This retrospective cohort study included patients newly diagnosed with asthma at Seoul National University Hospital from 2010 to 2017. Patients with comorbidities before the first visit (index date) that may increase anemia risk were excluded. Cox regression models adjusting for patient age, sex, and obesity were used to compare anemia hazard ratios (HRs) between asthma patients (n=1354) and healthy adults (n=1731). RESULTS: This study included 3085 patients. During 5-y follow-up, anemia occurred in 203 (15.0%) patients with asthma and 79 (4.6%) healthy adults. Compared with healthy adults, the HR for anemia after adjusting for age, sex, and obesity was 4.06 (95% CI: 2.70–6.09) in patients with asthma. In patients aged 18–64.9 y, the adjusted HR of anemia was 3.27 (95% CI: 2.12–5.04) in patients with asthma, compared to healthy patients. In patients >65 y, this adjusted HR was 5.56 (95% CI: 1.31–23.67). CONCLUSION: The risk of anemia was increased in patients with asthma after adjusting for sex, age, and obesity and excluding comorbidities that can cause anemia. These results suggest the need for regular monitoring for anemia in patients with asthma. |
format | Online Article Text |
id | pubmed-9830059 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-98300592023-01-11 Increased Risk of Anemia in Patients with Asthma Rhew, Kiyon Choi, Jisu Kim, Kyungim Choi, Kyung Hee Lee, So-Hee Park, Heung-Woo Clin Epidemiol Original Research PURPOSE: Asthma can cause a systemic inflammatory response, and anemia of chronic disease (ACD) is known to be caused by other disorders with a chronic inflammatory state. However, it is unclear whether the incidence of anemia is increased in patients with asthma. The objective of this study was to compare the incidence of anemia in patients with asthma and healthy adults. PATIENTS AND METHODS: This retrospective cohort study included patients newly diagnosed with asthma at Seoul National University Hospital from 2010 to 2017. Patients with comorbidities before the first visit (index date) that may increase anemia risk were excluded. Cox regression models adjusting for patient age, sex, and obesity were used to compare anemia hazard ratios (HRs) between asthma patients (n=1354) and healthy adults (n=1731). RESULTS: This study included 3085 patients. During 5-y follow-up, anemia occurred in 203 (15.0%) patients with asthma and 79 (4.6%) healthy adults. Compared with healthy adults, the HR for anemia after adjusting for age, sex, and obesity was 4.06 (95% CI: 2.70–6.09) in patients with asthma. In patients aged 18–64.9 y, the adjusted HR of anemia was 3.27 (95% CI: 2.12–5.04) in patients with asthma, compared to healthy patients. In patients >65 y, this adjusted HR was 5.56 (95% CI: 1.31–23.67). CONCLUSION: The risk of anemia was increased in patients with asthma after adjusting for sex, age, and obesity and excluding comorbidities that can cause anemia. These results suggest the need for regular monitoring for anemia in patients with asthma. Dove 2023-01-05 /pmc/articles/PMC9830059/ /pubmed/36636733 http://dx.doi.org/10.2147/CLEP.S394717 Text en © 2023 Rhew et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Rhew, Kiyon Choi, Jisu Kim, Kyungim Choi, Kyung Hee Lee, So-Hee Park, Heung-Woo Increased Risk of Anemia in Patients with Asthma |
title | Increased Risk of Anemia in Patients with Asthma |
title_full | Increased Risk of Anemia in Patients with Asthma |
title_fullStr | Increased Risk of Anemia in Patients with Asthma |
title_full_unstemmed | Increased Risk of Anemia in Patients with Asthma |
title_short | Increased Risk of Anemia in Patients with Asthma |
title_sort | increased risk of anemia in patients with asthma |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9830059/ https://www.ncbi.nlm.nih.gov/pubmed/36636733 http://dx.doi.org/10.2147/CLEP.S394717 |
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