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Coronavirus covid-19 detection by means of explainable deep learning

The coronavirus is caused by the infection of the SARS-CoV-2 virus: it represents a complex and new condition, considering that until the end of December 2019 this virus was totally unknown to the international scientific community. The clinical management of patients with the coronavirus disease ha...

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Autores principales: Mercaldo, Francesco, Belfiore, Maria Paola, Reginelli, Alfonso, Brunese, Luca, Santone, Antonella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9830129/
https://www.ncbi.nlm.nih.gov/pubmed/36627339
http://dx.doi.org/10.1038/s41598-023-27697-y
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author Mercaldo, Francesco
Belfiore, Maria Paola
Reginelli, Alfonso
Brunese, Luca
Santone, Antonella
author_facet Mercaldo, Francesco
Belfiore, Maria Paola
Reginelli, Alfonso
Brunese, Luca
Santone, Antonella
author_sort Mercaldo, Francesco
collection PubMed
description The coronavirus is caused by the infection of the SARS-CoV-2 virus: it represents a complex and new condition, considering that until the end of December 2019 this virus was totally unknown to the international scientific community. The clinical management of patients with the coronavirus disease has undergone an evolution over the months, thanks to the increasing knowledge of the virus, symptoms and efficacy of the various therapies. Currently, however, there is no specific therapy for SARS-CoV-2 virus, know also as Coronavirus disease 19, and treatment is based on the symptoms of the patient taking into account the overall clinical picture. Furthermore, the test to identify whether a patient is affected by the virus is generally performed on sputum and the result is generally available within a few hours or days. Researches previously found that the biomedical imaging analysis is able to show signs of pneumonia. For this reason in this paper, with the aim of providing a fully automatic and faster diagnosis, we design and implement a method adopting deep learning for the novel coronavirus disease detection, starting from computed tomography medical images. The proposed approach is aimed to detect whether a computed tomography medical images is related to an healthy patient, to a patient with a pulmonary disease or to a patient affected with Coronavirus disease 19. In case the patient is marked by the proposed method as affected by the Coronavirus disease 19, the areas symptomatic of the Coronavirus disease 19 infection are automatically highlighted in the computed tomography medical images. We perform an experimental analysis to empirically demonstrate the effectiveness of the proposed approach, by considering medical images belonging from different institutions, with an average time for Coronavirus disease 19 detection of approximately 8.9 s and an accuracy equal to 0.95.
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spelling pubmed-98301292023-01-10 Coronavirus covid-19 detection by means of explainable deep learning Mercaldo, Francesco Belfiore, Maria Paola Reginelli, Alfonso Brunese, Luca Santone, Antonella Sci Rep Article The coronavirus is caused by the infection of the SARS-CoV-2 virus: it represents a complex and new condition, considering that until the end of December 2019 this virus was totally unknown to the international scientific community. The clinical management of patients with the coronavirus disease has undergone an evolution over the months, thanks to the increasing knowledge of the virus, symptoms and efficacy of the various therapies. Currently, however, there is no specific therapy for SARS-CoV-2 virus, know also as Coronavirus disease 19, and treatment is based on the symptoms of the patient taking into account the overall clinical picture. Furthermore, the test to identify whether a patient is affected by the virus is generally performed on sputum and the result is generally available within a few hours or days. Researches previously found that the biomedical imaging analysis is able to show signs of pneumonia. For this reason in this paper, with the aim of providing a fully automatic and faster diagnosis, we design and implement a method adopting deep learning for the novel coronavirus disease detection, starting from computed tomography medical images. The proposed approach is aimed to detect whether a computed tomography medical images is related to an healthy patient, to a patient with a pulmonary disease or to a patient affected with Coronavirus disease 19. In case the patient is marked by the proposed method as affected by the Coronavirus disease 19, the areas symptomatic of the Coronavirus disease 19 infection are automatically highlighted in the computed tomography medical images. We perform an experimental analysis to empirically demonstrate the effectiveness of the proposed approach, by considering medical images belonging from different institutions, with an average time for Coronavirus disease 19 detection of approximately 8.9 s and an accuracy equal to 0.95. Nature Publishing Group UK 2023-01-10 /pmc/articles/PMC9830129/ /pubmed/36627339 http://dx.doi.org/10.1038/s41598-023-27697-y Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Mercaldo, Francesco
Belfiore, Maria Paola
Reginelli, Alfonso
Brunese, Luca
Santone, Antonella
Coronavirus covid-19 detection by means of explainable deep learning
title Coronavirus covid-19 detection by means of explainable deep learning
title_full Coronavirus covid-19 detection by means of explainable deep learning
title_fullStr Coronavirus covid-19 detection by means of explainable deep learning
title_full_unstemmed Coronavirus covid-19 detection by means of explainable deep learning
title_short Coronavirus covid-19 detection by means of explainable deep learning
title_sort coronavirus covid-19 detection by means of explainable deep learning
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9830129/
https://www.ncbi.nlm.nih.gov/pubmed/36627339
http://dx.doi.org/10.1038/s41598-023-27697-y
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