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Preparation and in vitro evaluation of hot-melt extruded pectin-based pellets containing ketoprofen for colon targeting

This work developed high drug-load pellets for colon targeting in minimal steps by coupling hot-melt extrusion (HME) with a die-surface cutting pelletizer, offering a potential continuous pellet manufacturing process. Ketoprofen (KTP) was selected as a model drug for this study due to its thermal st...

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Detalles Bibliográficos
Autores principales:	Narala, Sagar, Nyavanandi, Dinesh, Mandati, Preethi, Youssef, Ahmed Adel Ali, Alzahrani, Abdullah, Kolimi, Praveen, Zhang, Feng, Repka, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9830203/ https://www.ncbi.nlm.nih.gov/pubmed/36636366 http://dx.doi.org/10.1016/j.ijpx.2022.100156

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