Deep mutational analysis of elongation factor eEF2 residues implicated in human disease to identify functionally important contacts with the ribosome

An emerging body of research is revealing mutations in elongation factor eEF2 that are implicated in both inherited and de novo neurodevelopmental disorders. Previous structural analysis has revealed that most pathogenic amino acid substitutions map to the three main points of contact between eEF2 a...

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Detalles Bibliográficos
Autores principales: Olson, Alexandra N., Song, Serena, Dinman, Jonathan D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9830224/
https://www.ncbi.nlm.nih.gov/pubmed/36470424
http://dx.doi.org/10.1016/j.jbc.2022.102771

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9830224/
https://www.ncbi.nlm.nih.gov/pubmed/36470424
http://dx.doi.org/10.1016/j.jbc.2022.102771

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