On-demand biomanufacturing through synthetic biology approach

Biopharmaceuticals including protein therapeutics, engineered protein-based vaccines and monoclonal antibodies, are currently the mainstay products of the biotechnology industry. However, the need for specialized equipment and refrigeration during production and distribution poses challenges for the...

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Detalles Bibliográficos
Autores principales: Tang, Chenwang, Wang, Lin, Zang, Lei, Wang, Qing, Qi, Dianpeng, Dai, Zhuojun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Living Materials edited by Chao Zhong
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9830231/
https://www.ncbi.nlm.nih.gov/pubmed/36636637
http://dx.doi.org/10.1016/j.mtbio.2022.100518
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author Tang, Chenwang
Wang, Lin
Zang, Lei
Wang, Qing
Qi, Dianpeng
Dai, Zhuojun
author_facet Tang, Chenwang
Wang, Lin
Zang, Lei
Wang, Qing
Qi, Dianpeng
Dai, Zhuojun
author_sort Tang, Chenwang
collection PubMed
description Biopharmaceuticals including protein therapeutics, engineered protein-based vaccines and monoclonal antibodies, are currently the mainstay products of the biotechnology industry. However, the need for specialized equipment and refrigeration during production and distribution poses challenges for the delivery of these technologies to the field and low-resource area. With the development of synthetic biology, multiple studies rewire the cell-free system or living cells to impact the portable, on-site and on-demand manufacturing of biomolecules. Here, we review these efforts and suggest future directions.
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spelling pubmed-98302312023-01-11 On-demand biomanufacturing through synthetic biology approach Tang, Chenwang Wang, Lin Zang, Lei Wang, Qing Qi, Dianpeng Dai, Zhuojun Mater Today Bio Living Materials edited by Chao Zhong Biopharmaceuticals including protein therapeutics, engineered protein-based vaccines and monoclonal antibodies, are currently the mainstay products of the biotechnology industry. However, the need for specialized equipment and refrigeration during production and distribution poses challenges for the delivery of these technologies to the field and low-resource area. With the development of synthetic biology, multiple studies rewire the cell-free system or living cells to impact the portable, on-site and on-demand manufacturing of biomolecules. Here, we review these efforts and suggest future directions. Elsevier 2022-12-15 /pmc/articles/PMC9830231/ /pubmed/36636637 http://dx.doi.org/10.1016/j.mtbio.2022.100518 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Living Materials edited by Chao Zhong
Tang, Chenwang
Wang, Lin
Zang, Lei
Wang, Qing
Qi, Dianpeng
Dai, Zhuojun
On-demand biomanufacturing through synthetic biology approach
title On-demand biomanufacturing through synthetic biology approach
title_full On-demand biomanufacturing through synthetic biology approach
title_fullStr On-demand biomanufacturing through synthetic biology approach
title_full_unstemmed On-demand biomanufacturing through synthetic biology approach
title_short On-demand biomanufacturing through synthetic biology approach
title_sort on-demand biomanufacturing through synthetic biology approach
topic Living Materials edited by Chao Zhong
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9830231/
https://www.ncbi.nlm.nih.gov/pubmed/36636637
http://dx.doi.org/10.1016/j.mtbio.2022.100518
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