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Rhabdomyolysis after COVID-19 Comirnaty Vaccination: A Case Report
Rhabdomyolysis is an acute disruption in skeletal muscle integrity, leading to the rapid release of 4 muscle contents into the bloodstream, such as creatine kinase (CK). It can have various causes, including infections. Throughout the pandemic, multiple cases of rhabdomyolysis following COVID-19 inf...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
S. Karger AG
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9830288/ https://www.ncbi.nlm.nih.gov/pubmed/36636276 http://dx.doi.org/10.1159/000527599 |
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author | Ruijters, Veerle J. van der Meulen, Marjon F.G. van Es, Michael A. Smit, Tessa Hoogendijk, Jessica E. |
author_facet | Ruijters, Veerle J. van der Meulen, Marjon F.G. van Es, Michael A. Smit, Tessa Hoogendijk, Jessica E. |
author_sort | Ruijters, Veerle J. |
collection | PubMed |
description | Rhabdomyolysis is an acute disruption in skeletal muscle integrity, leading to the rapid release of 4 muscle contents into the bloodstream, such as creatine kinase (CK). It can have various causes, including infections. Throughout the pandemic, multiple cases of rhabdomyolysis following COVID-19 infections have been reported. However, rhabdomyolysis subsequent to COVID-19 vaccinations appears to be relatively rare. Here, we report such a case after a second COVID-19 Comirnaty (BioNTech/Pfizer) vaccination. Our patient developed rhabdomyolysis 1 day after the second Comirnaty vaccination with high creatine kinase (CK) levels, generalized weakness, and kidney failure. CK levels and muscle weakness resolved after treatment with intravenous fluids, but unfortunately, he remained hemodialysis dependent after discharge. To our knowledge, this is one of the first case reports describing a patient with rhabdomyolysis after a Comirnaty vaccination. However, as millions of people have received the Comirnaty vaccine, it is unclear whether the rhabdomyolysis in our patient is a rare side effect or an unrelated, coincidental event. Large observational studies are needed to elucidate the causality between the Comirnaty vaccination and rhabdomyolysis. Awareness is warranted in patients with myalgia and muscle weakness shortly after COVID-19 vaccination, in order to initiate treatment early and prevent life-threatening complications. |
format | Online Article Text |
id | pubmed-9830288 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | S. Karger AG |
record_format | MEDLINE/PubMed |
spelling | pubmed-98302882023-01-11 Rhabdomyolysis after COVID-19 Comirnaty Vaccination: A Case Report Ruijters, Veerle J. van der Meulen, Marjon F.G. van Es, Michael A. Smit, Tessa Hoogendijk, Jessica E. Case Rep Neurol Single Case − General Neurology Rhabdomyolysis is an acute disruption in skeletal muscle integrity, leading to the rapid release of 4 muscle contents into the bloodstream, such as creatine kinase (CK). It can have various causes, including infections. Throughout the pandemic, multiple cases of rhabdomyolysis following COVID-19 infections have been reported. However, rhabdomyolysis subsequent to COVID-19 vaccinations appears to be relatively rare. Here, we report such a case after a second COVID-19 Comirnaty (BioNTech/Pfizer) vaccination. Our patient developed rhabdomyolysis 1 day after the second Comirnaty vaccination with high creatine kinase (CK) levels, generalized weakness, and kidney failure. CK levels and muscle weakness resolved after treatment with intravenous fluids, but unfortunately, he remained hemodialysis dependent after discharge. To our knowledge, this is one of the first case reports describing a patient with rhabdomyolysis after a Comirnaty vaccination. However, as millions of people have received the Comirnaty vaccine, it is unclear whether the rhabdomyolysis in our patient is a rare side effect or an unrelated, coincidental event. Large observational studies are needed to elucidate the causality between the Comirnaty vaccination and rhabdomyolysis. Awareness is warranted in patients with myalgia and muscle weakness shortly after COVID-19 vaccination, in order to initiate treatment early and prevent life-threatening complications. S. Karger AG 2022-11-04 /pmc/articles/PMC9830288/ /pubmed/36636276 http://dx.doi.org/10.1159/000527599 Text en Copyright © 2022 by The Author(s). Published by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission. |
spellingShingle | Single Case − General Neurology Ruijters, Veerle J. van der Meulen, Marjon F.G. van Es, Michael A. Smit, Tessa Hoogendijk, Jessica E. Rhabdomyolysis after COVID-19 Comirnaty Vaccination: A Case Report |
title | Rhabdomyolysis after COVID-19 Comirnaty Vaccination: A Case Report |
title_full | Rhabdomyolysis after COVID-19 Comirnaty Vaccination: A Case Report |
title_fullStr | Rhabdomyolysis after COVID-19 Comirnaty Vaccination: A Case Report |
title_full_unstemmed | Rhabdomyolysis after COVID-19 Comirnaty Vaccination: A Case Report |
title_short | Rhabdomyolysis after COVID-19 Comirnaty Vaccination: A Case Report |
title_sort | rhabdomyolysis after covid-19 comirnaty vaccination: a case report |
topic | Single Case − General Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9830288/ https://www.ncbi.nlm.nih.gov/pubmed/36636276 http://dx.doi.org/10.1159/000527599 |
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