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Microbiota-induced lipid peroxidation impairs obeticholic acid-mediated antifibrotic effect towards nonalcoholic steatohepatitis in mice

Obeticholic acid (OCA) has been examined to treat non-alcoholic steatohepatitis (NASH), but has unsatisfactory antifibrotic effect and deficient responsive rate in recent phase III clinical trial. Using a prolonged western diet-feeding murine NASH model, we show that OCA-shaped gut microbiota induce...

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Detalles Bibliográficos
Autores principales:	Zhuge, Aoxiang, Li, Shengjie, Yuan, Yin, Han, Shengyi, Xia, Jiafeng, Wang, Qiangqiang, Wang, Shuting, Lou, Pengcheng, Li, Bo, Li, Lanjuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9830314/ https://www.ncbi.nlm.nih.gov/pubmed/36584600 http://dx.doi.org/10.1016/j.redox.2022.102582

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