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Altered engagement of the speech motor network is associated with reduced phonological working memory in autism

Nonword repetition, a common clinical measure of phonological working memory, involves component processes of speech perception, working memory, and speech production. Autistic children often show behavioral challenges in nonword repetition, as do many individuals with communication disorders. It is...

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Autores principales: O'Brien, Amanda M., Perrachione, Tyler K., Wisman Weil, Lisa, Sanchez Araujo, Yoel, Halverson, Kelly, Harris, Adrianne, Ostrovskaya, Irina, Kjelgaard, Margaret, Kenneth Wexler, Tager-Flusberg, Helen, Gabrieli, John D.E., Qi, Zhenghan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9830373/
https://www.ncbi.nlm.nih.gov/pubmed/36584426
http://dx.doi.org/10.1016/j.nicl.2022.103299
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author O'Brien, Amanda M.
Perrachione, Tyler K.
Wisman Weil, Lisa
Sanchez Araujo, Yoel
Halverson, Kelly
Harris, Adrianne
Ostrovskaya, Irina
Kjelgaard, Margaret
Kenneth Wexler
Tager-Flusberg, Helen
Gabrieli, John D.E.
Qi, Zhenghan
author_facet O'Brien, Amanda M.
Perrachione, Tyler K.
Wisman Weil, Lisa
Sanchez Araujo, Yoel
Halverson, Kelly
Harris, Adrianne
Ostrovskaya, Irina
Kjelgaard, Margaret
Kenneth Wexler
Tager-Flusberg, Helen
Gabrieli, John D.E.
Qi, Zhenghan
author_sort O'Brien, Amanda M.
collection PubMed
description Nonword repetition, a common clinical measure of phonological working memory, involves component processes of speech perception, working memory, and speech production. Autistic children often show behavioral challenges in nonword repetition, as do many individuals with communication disorders. It is unknown which subprocesses of phonological working memory are vulnerable in autistic individuals, and whether the same brain processes underlie the transdiagnostic difficulty with nonword repetition. We used functional magnetic resonance imaging (fMRI) to investigate the brain bases for nonword repetition challenges in autism. We compared activation during nonword repetition in functional brain networks subserving speech perception, working memory, and speech production between neurotypical and autistic children. Autistic children performed worse than neurotypical children on nonword repetition and had reduced activation in response to increasing phonological working memory load in the supplementary motor area. Multivoxel pattern analysis within the speech production network classified shorter vs longer nonword-repetition trials less accurately for autistic than neurotypical children. These speech production motor-specific differences were not observed in a group of children with reading disability who had similarly reduced nonword repetition behavior. These findings suggest that atypical function in speech production brain regions may contribute to nonword repetition difficulties in autism.
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spelling pubmed-98303732023-01-11 Altered engagement of the speech motor network is associated with reduced phonological working memory in autism O'Brien, Amanda M. Perrachione, Tyler K. Wisman Weil, Lisa Sanchez Araujo, Yoel Halverson, Kelly Harris, Adrianne Ostrovskaya, Irina Kjelgaard, Margaret Kenneth Wexler Tager-Flusberg, Helen Gabrieli, John D.E. Qi, Zhenghan Neuroimage Clin Regular Article Nonword repetition, a common clinical measure of phonological working memory, involves component processes of speech perception, working memory, and speech production. Autistic children often show behavioral challenges in nonword repetition, as do many individuals with communication disorders. It is unknown which subprocesses of phonological working memory are vulnerable in autistic individuals, and whether the same brain processes underlie the transdiagnostic difficulty with nonword repetition. We used functional magnetic resonance imaging (fMRI) to investigate the brain bases for nonword repetition challenges in autism. We compared activation during nonword repetition in functional brain networks subserving speech perception, working memory, and speech production between neurotypical and autistic children. Autistic children performed worse than neurotypical children on nonword repetition and had reduced activation in response to increasing phonological working memory load in the supplementary motor area. Multivoxel pattern analysis within the speech production network classified shorter vs longer nonword-repetition trials less accurately for autistic than neurotypical children. These speech production motor-specific differences were not observed in a group of children with reading disability who had similarly reduced nonword repetition behavior. These findings suggest that atypical function in speech production brain regions may contribute to nonword repetition difficulties in autism. Elsevier 2022-12-23 /pmc/articles/PMC9830373/ /pubmed/36584426 http://dx.doi.org/10.1016/j.nicl.2022.103299 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Regular Article
O'Brien, Amanda M.
Perrachione, Tyler K.
Wisman Weil, Lisa
Sanchez Araujo, Yoel
Halverson, Kelly
Harris, Adrianne
Ostrovskaya, Irina
Kjelgaard, Margaret
Kenneth Wexler
Tager-Flusberg, Helen
Gabrieli, John D.E.
Qi, Zhenghan
Altered engagement of the speech motor network is associated with reduced phonological working memory in autism
title Altered engagement of the speech motor network is associated with reduced phonological working memory in autism
title_full Altered engagement of the speech motor network is associated with reduced phonological working memory in autism
title_fullStr Altered engagement of the speech motor network is associated with reduced phonological working memory in autism
title_full_unstemmed Altered engagement of the speech motor network is associated with reduced phonological working memory in autism
title_short Altered engagement of the speech motor network is associated with reduced phonological working memory in autism
title_sort altered engagement of the speech motor network is associated with reduced phonological working memory in autism
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9830373/
https://www.ncbi.nlm.nih.gov/pubmed/36584426
http://dx.doi.org/10.1016/j.nicl.2022.103299
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