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Treatment of Achilles tendon partial injuries with injection of peripheral blood mononuclear cells (PB-MNCs): a case series

Three patients with Achilles tendon partial injury were treated with local injection of peripheral blood mononuclear cells (PB-MNCs). All subjects were evaluated both clinically (American Orthopedic Foot & Ankle Society - AOFAS scale) and radiologically (MRI examination) at 2 months, and a clini...

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Autores principales: Caravaggio, Francesco, Depalmi, Fabio, Antonelli, Michele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PAGEPress Publications, Pavia, Italy 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9830403/
https://www.ncbi.nlm.nih.gov/pubmed/36325915
http://dx.doi.org/10.4081/ejtm.2022.10768
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author Caravaggio, Francesco
Depalmi, Fabio
Antonelli, Michele
author_facet Caravaggio, Francesco
Depalmi, Fabio
Antonelli, Michele
author_sort Caravaggio, Francesco
collection PubMed
description Three patients with Achilles tendon partial injury were treated with local injection of peripheral blood mononuclear cells (PB-MNCs). All subjects were evaluated both clinically (American Orthopedic Foot & Ankle Society - AOFAS scale) and radiologically (MRI examination) at 2 months, and a clinical reassessment with the AOFAS scale was performed at 6 months. Functional and radiological signs of tendon healing processes were detected as early as 2 months after the procedure and the AOFAS scale rose from an initial average value of 37.0 to 82.7. Even though this study only involved a limited number of participants, our preliminary results indicate that regenerative therapies with PB-MNCs may be a valid alternative to surgical options for Achilles tendon partial injuries, especially in patients with contraindications to surgery, when other conservative approaches (exercises, physical therapies, sclerosing treatment) have failed. Further investigations on the subject seem rationally supported and advisable.
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spelling pubmed-98304032023-01-11 Treatment of Achilles tendon partial injuries with injection of peripheral blood mononuclear cells (PB-MNCs): a case series Caravaggio, Francesco Depalmi, Fabio Antonelli, Michele Eur J Transl Myol Article Three patients with Achilles tendon partial injury were treated with local injection of peripheral blood mononuclear cells (PB-MNCs). All subjects were evaluated both clinically (American Orthopedic Foot & Ankle Society - AOFAS scale) and radiologically (MRI examination) at 2 months, and a clinical reassessment with the AOFAS scale was performed at 6 months. Functional and radiological signs of tendon healing processes were detected as early as 2 months after the procedure and the AOFAS scale rose from an initial average value of 37.0 to 82.7. Even though this study only involved a limited number of participants, our preliminary results indicate that regenerative therapies with PB-MNCs may be a valid alternative to surgical options for Achilles tendon partial injuries, especially in patients with contraindications to surgery, when other conservative approaches (exercises, physical therapies, sclerosing treatment) have failed. Further investigations on the subject seem rationally supported and advisable. PAGEPress Publications, Pavia, Italy 2022-11-02 /pmc/articles/PMC9830403/ /pubmed/36325915 http://dx.doi.org/10.4081/ejtm.2022.10768 Text en https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution Noncommercial License (by-nc 4.0) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Article
Caravaggio, Francesco
Depalmi, Fabio
Antonelli, Michele
Treatment of Achilles tendon partial injuries with injection of peripheral blood mononuclear cells (PB-MNCs): a case series
title Treatment of Achilles tendon partial injuries with injection of peripheral blood mononuclear cells (PB-MNCs): a case series
title_full Treatment of Achilles tendon partial injuries with injection of peripheral blood mononuclear cells (PB-MNCs): a case series
title_fullStr Treatment of Achilles tendon partial injuries with injection of peripheral blood mononuclear cells (PB-MNCs): a case series
title_full_unstemmed Treatment of Achilles tendon partial injuries with injection of peripheral blood mononuclear cells (PB-MNCs): a case series
title_short Treatment of Achilles tendon partial injuries with injection of peripheral blood mononuclear cells (PB-MNCs): a case series
title_sort treatment of achilles tendon partial injuries with injection of peripheral blood mononuclear cells (pb-mncs): a case series
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9830403/
https://www.ncbi.nlm.nih.gov/pubmed/36325915
http://dx.doi.org/10.4081/ejtm.2022.10768
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