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Nanomaterial-based CT contrast agents and their applications in image-guided therapy
Computed tomography (CT), a diagnostic tool with clinical application, comprehensive coverage, and low cost, is used in hospitals worldwide. However, CT imaging fails to distinguish soft tissues from normal organs and tumors because their mass attenuation coefficients are similar. Various CT contras...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9830442/ https://www.ncbi.nlm.nih.gov/pubmed/36632234 http://dx.doi.org/10.7150/thno.79625 |
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author | Jiang, Zeyu Zhang, Meihua Li, Peifeng Wang, Yin Fu, Qinrui |
author_facet | Jiang, Zeyu Zhang, Meihua Li, Peifeng Wang, Yin Fu, Qinrui |
author_sort | Jiang, Zeyu |
collection | PubMed |
description | Computed tomography (CT), a diagnostic tool with clinical application, comprehensive coverage, and low cost, is used in hospitals worldwide. However, CT imaging fails to distinguish soft tissues from normal organs and tumors because their mass attenuation coefficients are similar. Various CT contrast agents have been developed in recent years to improve the sensitivity and contrast of imaging. Here, we review the progress of nanomaterial-based CT contrast agents and their applications in image-guided therapy. The CT contrast agents are classified according to their components; gold (Au)-based, bismuth (Bi)-based, lanthanide (Ln)-based, and transition metal (TM)-based nanomaterials are discussed. CT image-guided therapy of diseases, including photothermal therapy (PPT), photodynamic therapy (PDT), chemotherapy, radiotherapy (RT), gas therapy, sonodynamic therapy (SDT), immunotherapy, starvation therapy, gene therapy (GT), and microwave thermal therapy (MWTT), are reviewed. Finally, the perspectives on the CT contrast agents and their biomedical applications are discussed. |
format | Online Article Text |
id | pubmed-9830442 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-98304422023-01-10 Nanomaterial-based CT contrast agents and their applications in image-guided therapy Jiang, Zeyu Zhang, Meihua Li, Peifeng Wang, Yin Fu, Qinrui Theranostics Review Computed tomography (CT), a diagnostic tool with clinical application, comprehensive coverage, and low cost, is used in hospitals worldwide. However, CT imaging fails to distinguish soft tissues from normal organs and tumors because their mass attenuation coefficients are similar. Various CT contrast agents have been developed in recent years to improve the sensitivity and contrast of imaging. Here, we review the progress of nanomaterial-based CT contrast agents and their applications in image-guided therapy. The CT contrast agents are classified according to their components; gold (Au)-based, bismuth (Bi)-based, lanthanide (Ln)-based, and transition metal (TM)-based nanomaterials are discussed. CT image-guided therapy of diseases, including photothermal therapy (PPT), photodynamic therapy (PDT), chemotherapy, radiotherapy (RT), gas therapy, sonodynamic therapy (SDT), immunotherapy, starvation therapy, gene therapy (GT), and microwave thermal therapy (MWTT), are reviewed. Finally, the perspectives on the CT contrast agents and their biomedical applications are discussed. Ivyspring International Publisher 2023-01-01 /pmc/articles/PMC9830442/ /pubmed/36632234 http://dx.doi.org/10.7150/thno.79625 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
spellingShingle | Review Jiang, Zeyu Zhang, Meihua Li, Peifeng Wang, Yin Fu, Qinrui Nanomaterial-based CT contrast agents and their applications in image-guided therapy |
title | Nanomaterial-based CT contrast agents and their applications in image-guided therapy |
title_full | Nanomaterial-based CT contrast agents and their applications in image-guided therapy |
title_fullStr | Nanomaterial-based CT contrast agents and their applications in image-guided therapy |
title_full_unstemmed | Nanomaterial-based CT contrast agents and their applications in image-guided therapy |
title_short | Nanomaterial-based CT contrast agents and their applications in image-guided therapy |
title_sort | nanomaterial-based ct contrast agents and their applications in image-guided therapy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9830442/ https://www.ncbi.nlm.nih.gov/pubmed/36632234 http://dx.doi.org/10.7150/thno.79625 |
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