Combining the best of both worlds: radical-based divergent total synthesis

A mature science, combining the art of the total synthesis of complex natural structures and the practicality of delivering highly diverged lead compounds for biological screening, is the constant aim of the organic chemistry community. Delivering natural lead compounds became easier during the last...

Descripción completa

Detalles Bibliográficos
Autores principales: Gennaiou, Kyriaki, Kelesidis, Antonios, Kourgiantaki, Maria, Zografos, Alexandros L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9830495/
https://www.ncbi.nlm.nih.gov/pubmed/36686041
http://dx.doi.org/10.3762/bjoc.19.1
_version_ 1784867682302033920
author Gennaiou, Kyriaki
Kelesidis, Antonios
Kourgiantaki, Maria
Zografos, Alexandros L
author_facet Gennaiou, Kyriaki
Kelesidis, Antonios
Kourgiantaki, Maria
Zografos, Alexandros L
author_sort Gennaiou, Kyriaki
collection PubMed
description A mature science, combining the art of the total synthesis of complex natural structures and the practicality of delivering highly diverged lead compounds for biological screening, is the constant aim of the organic chemistry community. Delivering natural lead compounds became easier during the last two decades, with the evolution of green chemistry and the concepts of atom economy and protecting-group-free synthesis dominating the field of total synthesis. In this new era, total synthesis is moving towards natural efficacy by utilizing both the biosynthetic knowledge of divergent synthesis and the latest developments in radical chemistry. This contemporary review highlights recent total syntheses that incorporate the best of both worlds.
format Online
Article
Text
id pubmed-9830495
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Beilstein-Institut
record_format MEDLINE/PubMed
spelling pubmed-98304952023-01-20 Combining the best of both worlds: radical-based divergent total synthesis Gennaiou, Kyriaki Kelesidis, Antonios Kourgiantaki, Maria Zografos, Alexandros L Beilstein J Org Chem Review A mature science, combining the art of the total synthesis of complex natural structures and the practicality of delivering highly diverged lead compounds for biological screening, is the constant aim of the organic chemistry community. Delivering natural lead compounds became easier during the last two decades, with the evolution of green chemistry and the concepts of atom economy and protecting-group-free synthesis dominating the field of total synthesis. In this new era, total synthesis is moving towards natural efficacy by utilizing both the biosynthetic knowledge of divergent synthesis and the latest developments in radical chemistry. This contemporary review highlights recent total syntheses that incorporate the best of both worlds. Beilstein-Institut 2023-01-02 /pmc/articles/PMC9830495/ /pubmed/36686041 http://dx.doi.org/10.3762/bjoc.19.1 Text en Copyright © 2023, Gennaiou et al. https://creativecommons.org/licenses/by/4.0/This is an open access article licensed under the terms of the Beilstein-Institut Open Access License Agreement (https://www.beilstein-journals.org/bjoc/terms/terms), which is identical to the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/) ). The reuse of material under this license requires that the author(s), source and license are credited. Third-party material in this article could be subject to other licenses (typically indicated in the credit line), and in this case, users are required to obtain permission from the license holder to reuse the material.
spellingShingle Review
Gennaiou, Kyriaki
Kelesidis, Antonios
Kourgiantaki, Maria
Zografos, Alexandros L
Combining the best of both worlds: radical-based divergent total synthesis
title Combining the best of both worlds: radical-based divergent total synthesis
title_full Combining the best of both worlds: radical-based divergent total synthesis
title_fullStr Combining the best of both worlds: radical-based divergent total synthesis
title_full_unstemmed Combining the best of both worlds: radical-based divergent total synthesis
title_short Combining the best of both worlds: radical-based divergent total synthesis
title_sort combining the best of both worlds: radical-based divergent total synthesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9830495/
https://www.ncbi.nlm.nih.gov/pubmed/36686041
http://dx.doi.org/10.3762/bjoc.19.1
work_keys_str_mv AT gennaioukyriaki combiningthebestofbothworldsradicalbaseddivergenttotalsynthesis
AT kelesidisantonios combiningthebestofbothworldsradicalbaseddivergenttotalsynthesis
AT kourgiantakimaria combiningthebestofbothworldsradicalbaseddivergenttotalsynthesis
AT zografosalexandrosl combiningthebestofbothworldsradicalbaseddivergenttotalsynthesis

Ejemplares similares