Synthesis of Benzofuropyridines and Dibenzofurans by a Metalation/Negishi Cross-Coupling/S(N)Ar Reaction Sequence

[Image: see text] An efficient methodology for the synthesis of benzofuropyridines and dibenzofurans from fluoropyridines or fluoroarenes and 2-bromophenyl acetates is reported. This streamlined one-pot procedure consists of a four-step directed ortho-lithiation, zincation, Negishi cross-coupling, a...

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Autores principales: Clarkson, Guy J., Roesner, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9830636/
https://www.ncbi.nlm.nih.gov/pubmed/36484714
http://dx.doi.org/10.1021/acs.joc.2c02111
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author Clarkson, Guy J.
Roesner, Stefan
author_facet Clarkson, Guy J.
Roesner, Stefan
author_sort Clarkson, Guy J.
collection PubMed
description [Image: see text] An efficient methodology for the synthesis of benzofuropyridines and dibenzofurans from fluoropyridines or fluoroarenes and 2-bromophenyl acetates is reported. This streamlined one-pot procedure consists of a four-step directed ortho-lithiation, zincation, Negishi cross-coupling, and intramolecular nucleophilic aromatic substitution, allowing for the facile assembly of a diverse set of fused benzofuro heterocycles.
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spelling pubmed-98306362023-01-11 Synthesis of Benzofuropyridines and Dibenzofurans by a Metalation/Negishi Cross-Coupling/S(N)Ar Reaction Sequence Clarkson, Guy J. Roesner, Stefan J Org Chem [Image: see text] An efficient methodology for the synthesis of benzofuropyridines and dibenzofurans from fluoropyridines or fluoroarenes and 2-bromophenyl acetates is reported. This streamlined one-pot procedure consists of a four-step directed ortho-lithiation, zincation, Negishi cross-coupling, and intramolecular nucleophilic aromatic substitution, allowing for the facile assembly of a diverse set of fused benzofuro heterocycles. American Chemical Society 2022-12-09 2023-01-06 /pmc/articles/PMC9830636/ /pubmed/36484714 http://dx.doi.org/10.1021/acs.joc.2c02111 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Clarkson, Guy J.
Roesner, Stefan
Synthesis of Benzofuropyridines and Dibenzofurans by a Metalation/Negishi Cross-Coupling/S(N)Ar Reaction Sequence
title Synthesis of Benzofuropyridines and Dibenzofurans by a Metalation/Negishi Cross-Coupling/S(N)Ar Reaction Sequence
title_full Synthesis of Benzofuropyridines and Dibenzofurans by a Metalation/Negishi Cross-Coupling/S(N)Ar Reaction Sequence
title_fullStr Synthesis of Benzofuropyridines and Dibenzofurans by a Metalation/Negishi Cross-Coupling/S(N)Ar Reaction Sequence
title_full_unstemmed Synthesis of Benzofuropyridines and Dibenzofurans by a Metalation/Negishi Cross-Coupling/S(N)Ar Reaction Sequence
title_short Synthesis of Benzofuropyridines and Dibenzofurans by a Metalation/Negishi Cross-Coupling/S(N)Ar Reaction Sequence
title_sort synthesis of benzofuropyridines and dibenzofurans by a metalation/negishi cross-coupling/s(n)ar reaction sequence
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9830636/
https://www.ncbi.nlm.nih.gov/pubmed/36484714
http://dx.doi.org/10.1021/acs.joc.2c02111
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