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A Case of Non-cutaneous Kaposi Sarcoma

Kaposi sarcoma is a malignancy common in patients with acquired immune deficiency syndrome (AIDS). It is a proliferative soft-tissue tumor commonly manifesting as pigmented papules and nodules on the skin. Lesions can also appear on the mucosal lining of the oropharynx and other parts of the body su...

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Autores principales: Osei, Noah, Fletcher, Gerald, Showunmi, Abosede, Ahluwalia, Meena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9830648/
https://www.ncbi.nlm.nih.gov/pubmed/36636532
http://dx.doi.org/10.7759/cureus.32394
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author Osei, Noah
Fletcher, Gerald
Showunmi, Abosede
Ahluwalia, Meena
author_facet Osei, Noah
Fletcher, Gerald
Showunmi, Abosede
Ahluwalia, Meena
author_sort Osei, Noah
collection PubMed
description Kaposi sarcoma is a malignancy common in patients with acquired immune deficiency syndrome (AIDS). It is a proliferative soft-tissue tumor commonly manifesting as pigmented papules and nodules on the skin. Lesions can also appear on the mucosal lining of the oropharynx and other parts of the body such as the lymph nodes. Head and neck involvement in Kaposi sarcoma is not unusual; however, laryngeal involvement is not commonly seen. We report the case of a 31-year-old gentleman, a former smoker with AIDS, who developed a mass in the throat with progressive hoarseness of voice without stridor. An elective tracheostomy was done to protect his airway before performing a direct laryngoscopy with biopsy. Histopathology examination showed neoplastic spindle cells positive for CD31, erythroblast transformation specific-related gene, and human herpesvirus 8, consistent with Kaposi sarcoma. The diagnosis of laryngeal Kaposi sarcoma in immunodeficient patients requires a high index of suspicion, especially when it occurs without classical dermatological manifestation, an interesting feature in this report.
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spelling pubmed-98306482023-01-11 A Case of Non-cutaneous Kaposi Sarcoma Osei, Noah Fletcher, Gerald Showunmi, Abosede Ahluwalia, Meena Cureus Internal Medicine Kaposi sarcoma is a malignancy common in patients with acquired immune deficiency syndrome (AIDS). It is a proliferative soft-tissue tumor commonly manifesting as pigmented papules and nodules on the skin. Lesions can also appear on the mucosal lining of the oropharynx and other parts of the body such as the lymph nodes. Head and neck involvement in Kaposi sarcoma is not unusual; however, laryngeal involvement is not commonly seen. We report the case of a 31-year-old gentleman, a former smoker with AIDS, who developed a mass in the throat with progressive hoarseness of voice without stridor. An elective tracheostomy was done to protect his airway before performing a direct laryngoscopy with biopsy. Histopathology examination showed neoplastic spindle cells positive for CD31, erythroblast transformation specific-related gene, and human herpesvirus 8, consistent with Kaposi sarcoma. The diagnosis of laryngeal Kaposi sarcoma in immunodeficient patients requires a high index of suspicion, especially when it occurs without classical dermatological manifestation, an interesting feature in this report. Cureus 2022-12-11 /pmc/articles/PMC9830648/ /pubmed/36636532 http://dx.doi.org/10.7759/cureus.32394 Text en Copyright © 2022, Osei et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Osei, Noah
Fletcher, Gerald
Showunmi, Abosede
Ahluwalia, Meena
A Case of Non-cutaneous Kaposi Sarcoma
title A Case of Non-cutaneous Kaposi Sarcoma
title_full A Case of Non-cutaneous Kaposi Sarcoma
title_fullStr A Case of Non-cutaneous Kaposi Sarcoma
title_full_unstemmed A Case of Non-cutaneous Kaposi Sarcoma
title_short A Case of Non-cutaneous Kaposi Sarcoma
title_sort case of non-cutaneous kaposi sarcoma
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9830648/
https://www.ncbi.nlm.nih.gov/pubmed/36636532
http://dx.doi.org/10.7759/cureus.32394
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