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Nitrate containing vegetables and dietary nitrate and nonalcoholic fatty liver disease: a case control study

BACKGROUND: Vegetables is the main sources of dietary nitrate. Studies suggested the potential link between nitrate content of vegetables and reduce the risk of chronic diseases. We aimed to assess the association between nitrate-containing vegetables (NCVs) with odds of nonalcoholic fatty liver dis...

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Autores principales: Mirmiran, Parvin, Teymoori, Farshad, Farhadnejad, Hossein, Mokhtari, Ebrahim, Salehi-Sahlabadi, Ammar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9830756/
https://www.ncbi.nlm.nih.gov/pubmed/36627671
http://dx.doi.org/10.1186/s12937-023-00834-z
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author Mirmiran, Parvin
Teymoori, Farshad
Farhadnejad, Hossein
Mokhtari, Ebrahim
Salehi-Sahlabadi, Ammar
author_facet Mirmiran, Parvin
Teymoori, Farshad
Farhadnejad, Hossein
Mokhtari, Ebrahim
Salehi-Sahlabadi, Ammar
author_sort Mirmiran, Parvin
collection PubMed
description BACKGROUND: Vegetables is the main sources of dietary nitrate. Studies suggested the potential link between nitrate content of vegetables and reduce the risk of chronic diseases. We aimed to assess the association between nitrate-containing vegetables (NCVs) with odds of nonalcoholic fatty liver diseases (NAFLD) in Iranian adults. METHOD: This case-control study was performed on a total of 225 newly diagnosed NAFLD cases and 450 controls aged 20–60 years. Individuals’ dietary intakes were determined using a valid and reliable food frequency questionnaire. RESULTS: The mean ± SD age and BMI of participants were 38.1 ± 8.8 years and 26.8 ± 4.3 kg/m(2), respectively. In the fully adjusted model, the odds of NAFLD were decreased across tertiles of total NCVs [(adjusted OR: 0.20, 95%CI: 0.10–0.40), (P(trend) <  0.001)] and low-nitrate vegetables [(adjusted OR: 0.22, 95%CI: 0.11–0.48), (P(trend) <  0.001)]. Our results showed that each one SD increments in nitrate content of vegetables (adjusted OR: 0.73, 95%CI: 0.55–0.97) and nitrate content of fruits (adjusted OR: 0.59, 95%CI: 0.36–0.97) was associated with reduced odds of NAFLD (P <  0.05). However, there was a positive association between each one SD increments in nitrate content of dairy products and meats and processed meats with odds of NAFLD (adjusted OR: 1.34, 95%CI: 1.03–1.74), (P <  0.05). CONCLUSION: Our finding suggested that a higher intake of vegetable nitrate may be related to a decrease the odds of NAFLD.
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spelling pubmed-98307562023-01-11 Nitrate containing vegetables and dietary nitrate and nonalcoholic fatty liver disease: a case control study Mirmiran, Parvin Teymoori, Farshad Farhadnejad, Hossein Mokhtari, Ebrahim Salehi-Sahlabadi, Ammar Nutr J Research BACKGROUND: Vegetables is the main sources of dietary nitrate. Studies suggested the potential link between nitrate content of vegetables and reduce the risk of chronic diseases. We aimed to assess the association between nitrate-containing vegetables (NCVs) with odds of nonalcoholic fatty liver diseases (NAFLD) in Iranian adults. METHOD: This case-control study was performed on a total of 225 newly diagnosed NAFLD cases and 450 controls aged 20–60 years. Individuals’ dietary intakes were determined using a valid and reliable food frequency questionnaire. RESULTS: The mean ± SD age and BMI of participants were 38.1 ± 8.8 years and 26.8 ± 4.3 kg/m(2), respectively. In the fully adjusted model, the odds of NAFLD were decreased across tertiles of total NCVs [(adjusted OR: 0.20, 95%CI: 0.10–0.40), (P(trend) <  0.001)] and low-nitrate vegetables [(adjusted OR: 0.22, 95%CI: 0.11–0.48), (P(trend) <  0.001)]. Our results showed that each one SD increments in nitrate content of vegetables (adjusted OR: 0.73, 95%CI: 0.55–0.97) and nitrate content of fruits (adjusted OR: 0.59, 95%CI: 0.36–0.97) was associated with reduced odds of NAFLD (P <  0.05). However, there was a positive association between each one SD increments in nitrate content of dairy products and meats and processed meats with odds of NAFLD (adjusted OR: 1.34, 95%CI: 1.03–1.74), (P <  0.05). CONCLUSION: Our finding suggested that a higher intake of vegetable nitrate may be related to a decrease the odds of NAFLD. BioMed Central 2023-01-10 /pmc/articles/PMC9830756/ /pubmed/36627671 http://dx.doi.org/10.1186/s12937-023-00834-z Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Mirmiran, Parvin
Teymoori, Farshad
Farhadnejad, Hossein
Mokhtari, Ebrahim
Salehi-Sahlabadi, Ammar
Nitrate containing vegetables and dietary nitrate and nonalcoholic fatty liver disease: a case control study
title Nitrate containing vegetables and dietary nitrate and nonalcoholic fatty liver disease: a case control study
title_full Nitrate containing vegetables and dietary nitrate and nonalcoholic fatty liver disease: a case control study
title_fullStr Nitrate containing vegetables and dietary nitrate and nonalcoholic fatty liver disease: a case control study
title_full_unstemmed Nitrate containing vegetables and dietary nitrate and nonalcoholic fatty liver disease: a case control study
title_short Nitrate containing vegetables and dietary nitrate and nonalcoholic fatty liver disease: a case control study
title_sort nitrate containing vegetables and dietary nitrate and nonalcoholic fatty liver disease: a case control study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9830756/
https://www.ncbi.nlm.nih.gov/pubmed/36627671
http://dx.doi.org/10.1186/s12937-023-00834-z
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