Systemic inhibition of 5-lipoxygenase by MK-886 exacerbates apical periodontitis bone loss in a mouse model

BACKGROUND: To investigate if 5-LO selective inhibitor (MK-886) could be used for systemic treatment of experimentally induced apical periodontitis in a mouse model. METHODS: Twenty-four C57BL/6 mice were used. After coronal opening, a solution containing Escherichia coli LPS (1.0 µg/µL) was inocula...

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Detalles Bibliográficos
Autores principales: Petean, Igor Bassi Ferreira, Silva-Sousa, Alice Corrêa, da Silva, Raquel Assed Bezerra, Lucisano, Marília Pacífico, da Silva, Léa Assed Bezerra, de Castro, Guilherme Piedade Assed, Sousa-Neto, Manoel Damião, Faccioli, Lúcia Helena, Paula-Silva, Francisco Wanderley Garcia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9830793/
https://www.ncbi.nlm.nih.gov/pubmed/36624436
http://dx.doi.org/10.1186/s12903-023-02712-w

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