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GBCdb: RNA expression landscapes and ncRNA–mRNA interactions in gallbladder carcinoma

Gallbladder carcinoma (GBC), an aggressive malignant tumor of the biliary system, is characterized by high cellular heterogeneity and poor prognosis. Fewer data have been reported in GBC than other common cancer types. Multi-omics data will contribute to the understanding of the molecular mechanisms...

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Autores principales: Guo, Li, Xiang, Yangyang, Dou, Yuyang, Yin, Zibo, Xu, Xinru, Tang, Lihua, Yu, Jiafeng, Wang, Jun, Liang, Tingming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9830852/
https://www.ncbi.nlm.nih.gov/pubmed/36624399
http://dx.doi.org/10.1186/s12859-023-05133-2
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author Guo, Li
Xiang, Yangyang
Dou, Yuyang
Yin, Zibo
Xu, Xinru
Tang, Lihua
Yu, Jiafeng
Wang, Jun
Liang, Tingming
author_facet Guo, Li
Xiang, Yangyang
Dou, Yuyang
Yin, Zibo
Xu, Xinru
Tang, Lihua
Yu, Jiafeng
Wang, Jun
Liang, Tingming
author_sort Guo, Li
collection PubMed
description Gallbladder carcinoma (GBC), an aggressive malignant tumor of the biliary system, is characterized by high cellular heterogeneity and poor prognosis. Fewer data have been reported in GBC than other common cancer types. Multi-omics data will contribute to the understanding of the molecular mechanisms of cancer, cancer diagnosis and prognosis. Herein, to provide better understanding of the molecular events in GBC pathogenesis, we developed GBCdb (http://tmliang.cn/gbc/), a user-friendly interface for the query and browsing of GBC-associated genes and RNA interaction networks using published multi-omics data, which also included experimentally supported data from different molecular levels. GBCdb will help to elucidate the potential biological roles of different RNAs and allow for the exploration of RNA interactions in GBC. These resources will provide an opportunity for unraveling the potential molecular features of Gallbladder carcinoma. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12859-023-05133-2.
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spelling pubmed-98308522023-01-11 GBCdb: RNA expression landscapes and ncRNA–mRNA interactions in gallbladder carcinoma Guo, Li Xiang, Yangyang Dou, Yuyang Yin, Zibo Xu, Xinru Tang, Lihua Yu, Jiafeng Wang, Jun Liang, Tingming BMC Bioinformatics Database Gallbladder carcinoma (GBC), an aggressive malignant tumor of the biliary system, is characterized by high cellular heterogeneity and poor prognosis. Fewer data have been reported in GBC than other common cancer types. Multi-omics data will contribute to the understanding of the molecular mechanisms of cancer, cancer diagnosis and prognosis. Herein, to provide better understanding of the molecular events in GBC pathogenesis, we developed GBCdb (http://tmliang.cn/gbc/), a user-friendly interface for the query and browsing of GBC-associated genes and RNA interaction networks using published multi-omics data, which also included experimentally supported data from different molecular levels. GBCdb will help to elucidate the potential biological roles of different RNAs and allow for the exploration of RNA interactions in GBC. These resources will provide an opportunity for unraveling the potential molecular features of Gallbladder carcinoma. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12859-023-05133-2. BioMed Central 2023-01-09 /pmc/articles/PMC9830852/ /pubmed/36624399 http://dx.doi.org/10.1186/s12859-023-05133-2 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Database
Guo, Li
Xiang, Yangyang
Dou, Yuyang
Yin, Zibo
Xu, Xinru
Tang, Lihua
Yu, Jiafeng
Wang, Jun
Liang, Tingming
GBCdb: RNA expression landscapes and ncRNA–mRNA interactions in gallbladder carcinoma
title GBCdb: RNA expression landscapes and ncRNA–mRNA interactions in gallbladder carcinoma
title_full GBCdb: RNA expression landscapes and ncRNA–mRNA interactions in gallbladder carcinoma
title_fullStr GBCdb: RNA expression landscapes and ncRNA–mRNA interactions in gallbladder carcinoma
title_full_unstemmed GBCdb: RNA expression landscapes and ncRNA–mRNA interactions in gallbladder carcinoma
title_short GBCdb: RNA expression landscapes and ncRNA–mRNA interactions in gallbladder carcinoma
title_sort gbcdb: rna expression landscapes and ncrna–mrna interactions in gallbladder carcinoma
topic Database
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9830852/
https://www.ncbi.nlm.nih.gov/pubmed/36624399
http://dx.doi.org/10.1186/s12859-023-05133-2
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