Knockout of secretin ameliorates biliary and liver phenotypes during alcohol-induced hepatotoxicity

BACKGROUND: Alcohol-related liver disease (ALD) is characterized by ductular reaction (DR), liver inflammation, steatosis, fibrosis, and cirrhosis. The secretin (Sct)/secretin receptor (SR) axis (expressed only by cholangiocytes) regulates liver phenotypes in cholestasis. We evaluated the role of Sc...

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Detalles Bibliográficos
Autores principales: Kyritsi, Konstantina, Wu, Nan, Zhou, Tianhao, Carpino, Guido, Baiocchi, Leonardo, Kennedy, Lindsey, Chen, Lixian, Ceci, Ludovica, Meyer, Alison Ann, Barupala, Nipuni, Franchitto, Antonio, Onori, Paolo, Ekser, Burcin, Gaudio, Eugenio, Wu, Chaodong, Marakovits, Corinn, Chakraborty, Sanjukta, Francis, Heather, Glaser, Shannon, Alpini, Gianfranco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9830859/
https://www.ncbi.nlm.nih.gov/pubmed/36624475
http://dx.doi.org/10.1186/s13578-022-00945-w

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