Pragmatic cluster randomized trial to evaluate effectiveness and implementation of EHR-facilitated collaborative symptom control in cancer (E2C2): addendum

We previously described the hypotheses, outcomes, design, and analysis for E2C2, a pragmatic stepped-wedge trial to assess an intervention to improve symptom control in patients with cancer. Subsequent consideration of the design and cohort led to the addition of a second primary hypothesis. This ar...

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Autores principales: Herrin, Jeph, Finney Rutten, Lila J., Ruddy, Kathryn J., Kroenke, Kurt, Cheville, Andrea L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Update
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9830868/
https://www.ncbi.nlm.nih.gov/pubmed/36624460
http://dx.doi.org/10.1186/s13063-022-06983-6
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author Herrin, Jeph
Finney Rutten, Lila J.
Ruddy, Kathryn J.
Kroenke, Kurt
Cheville, Andrea L.
author_facet Herrin, Jeph
Finney Rutten, Lila J.
Ruddy, Kathryn J.
Kroenke, Kurt
Cheville, Andrea L.
author_sort Herrin, Jeph
collection PubMed
description We previously described the hypotheses, outcomes, design, and analysis for E2C2, a pragmatic stepped-wedge trial to assess an intervention to improve symptom control in patients with cancer. Subsequent consideration of the design and cohort led to the addition of a second primary hypothesis. This article describes and presents the rationale for this second hypothesis. This addendum also details a revised analytic approach, necessitated by inconsistencies in the original analytic plan. The design, outcomes, and other aspects of the protocol remain unchanged.
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spelling pubmed-98308682023-01-11 Pragmatic cluster randomized trial to evaluate effectiveness and implementation of EHR-facilitated collaborative symptom control in cancer (E2C2): addendum Herrin, Jeph Finney Rutten, Lila J. Ruddy, Kathryn J. Kroenke, Kurt Cheville, Andrea L. Trials Update We previously described the hypotheses, outcomes, design, and analysis for E2C2, a pragmatic stepped-wedge trial to assess an intervention to improve symptom control in patients with cancer. Subsequent consideration of the design and cohort led to the addition of a second primary hypothesis. This article describes and presents the rationale for this second hypothesis. This addendum also details a revised analytic approach, necessitated by inconsistencies in the original analytic plan. The design, outcomes, and other aspects of the protocol remain unchanged. BioMed Central 2023-01-09 /pmc/articles/PMC9830868/ /pubmed/36624460 http://dx.doi.org/10.1186/s13063-022-06983-6 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Update
Herrin, Jeph
Finney Rutten, Lila J.
Ruddy, Kathryn J.
Kroenke, Kurt
Cheville, Andrea L.
Pragmatic cluster randomized trial to evaluate effectiveness and implementation of EHR-facilitated collaborative symptom control in cancer (E2C2): addendum
title Pragmatic cluster randomized trial to evaluate effectiveness and implementation of EHR-facilitated collaborative symptom control in cancer (E2C2): addendum
title_full Pragmatic cluster randomized trial to evaluate effectiveness and implementation of EHR-facilitated collaborative symptom control in cancer (E2C2): addendum
title_fullStr Pragmatic cluster randomized trial to evaluate effectiveness and implementation of EHR-facilitated collaborative symptom control in cancer (E2C2): addendum
title_full_unstemmed Pragmatic cluster randomized trial to evaluate effectiveness and implementation of EHR-facilitated collaborative symptom control in cancer (E2C2): addendum
title_short Pragmatic cluster randomized trial to evaluate effectiveness and implementation of EHR-facilitated collaborative symptom control in cancer (E2C2): addendum
title_sort pragmatic cluster randomized trial to evaluate effectiveness and implementation of ehr-facilitated collaborative symptom control in cancer (e2c2): addendum
topic Update
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9830868/
https://www.ncbi.nlm.nih.gov/pubmed/36624460
http://dx.doi.org/10.1186/s13063-022-06983-6
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