Breast cancer heterogeneity and its implication in personalized precision therapy

Breast cancer heterogeneity determines cancer progression, treatment effects, and prognosis. However, the precise mechanism for this heterogeneity remains unknown owing to its complexity. Here, we summarize the origins of breast cancer heterogeneity and its influence on disease progression, recurren...

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Autores principales: Guo, Liantao, Kong, Deguang, Liu, Jianhua, Zhan, Ling, Luo, Lan, Zheng, Weijie, Zheng, Qingyuan, Chen, Chuang, Sun, Shengrong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9830930/
https://www.ncbi.nlm.nih.gov/pubmed/36624542
http://dx.doi.org/10.1186/s40164-022-00363-1
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author Guo, Liantao
Kong, Deguang
Liu, Jianhua
Zhan, Ling
Luo, Lan
Zheng, Weijie
Zheng, Qingyuan
Chen, Chuang
Sun, Shengrong
author_facet Guo, Liantao
Kong, Deguang
Liu, Jianhua
Zhan, Ling
Luo, Lan
Zheng, Weijie
Zheng, Qingyuan
Chen, Chuang
Sun, Shengrong
author_sort Guo, Liantao
collection PubMed
description Breast cancer heterogeneity determines cancer progression, treatment effects, and prognosis. However, the precise mechanism for this heterogeneity remains unknown owing to its complexity. Here, we summarize the origins of breast cancer heterogeneity and its influence on disease progression, recurrence, and therapeutic resistance. We review the possible mechanisms of heterogeneity and the research methods used to analyze it. We also highlight the importance of cell interactions for the origins of breast cancer heterogeneity, which can be further categorized into cooperative and competitive interactions. Finally, we provide new insights into precise individual treatments based on heterogeneity.
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spelling pubmed-98309302023-01-11 Breast cancer heterogeneity and its implication in personalized precision therapy Guo, Liantao Kong, Deguang Liu, Jianhua Zhan, Ling Luo, Lan Zheng, Weijie Zheng, Qingyuan Chen, Chuang Sun, Shengrong Exp Hematol Oncol Review Breast cancer heterogeneity determines cancer progression, treatment effects, and prognosis. However, the precise mechanism for this heterogeneity remains unknown owing to its complexity. Here, we summarize the origins of breast cancer heterogeneity and its influence on disease progression, recurrence, and therapeutic resistance. We review the possible mechanisms of heterogeneity and the research methods used to analyze it. We also highlight the importance of cell interactions for the origins of breast cancer heterogeneity, which can be further categorized into cooperative and competitive interactions. Finally, we provide new insights into precise individual treatments based on heterogeneity. BioMed Central 2023-01-09 /pmc/articles/PMC9830930/ /pubmed/36624542 http://dx.doi.org/10.1186/s40164-022-00363-1 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Guo, Liantao
Kong, Deguang
Liu, Jianhua
Zhan, Ling
Luo, Lan
Zheng, Weijie
Zheng, Qingyuan
Chen, Chuang
Sun, Shengrong
Breast cancer heterogeneity and its implication in personalized precision therapy
title Breast cancer heterogeneity and its implication in personalized precision therapy
title_full Breast cancer heterogeneity and its implication in personalized precision therapy
title_fullStr Breast cancer heterogeneity and its implication in personalized precision therapy
title_full_unstemmed Breast cancer heterogeneity and its implication in personalized precision therapy
title_short Breast cancer heterogeneity and its implication in personalized precision therapy
title_sort breast cancer heterogeneity and its implication in personalized precision therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9830930/
https://www.ncbi.nlm.nih.gov/pubmed/36624542
http://dx.doi.org/10.1186/s40164-022-00363-1
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