Senescent stroma induces nuclear deformations in cancer cells via the inhibition of RhoA/ROCK/myosin II-based cytoskeletal tension

The presence of senescent cells within tissues has been functionally linked to malignant transformations. Here, using tension-gauge tethers technology, particle-tracking microrheology, and quantitative microscopy, we demonstrate that senescent-associated secretory phenotype (SASP) derived from senes...

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Detalles Bibliográficos
Autores principales: Aifuwa, Ivie, Kim, Byoung Choul, Kamat, Pratik, Starich, Bartholomew, Agrawal, Anshika, Tanrioven, Derin, Luperchio, Teresa R, Valencia, Angela M Jimenez, Perestrelo, Tania, Reddy, Karen, Ha, Taekjip, Philip, Jude M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Research Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9830950/
https://www.ncbi.nlm.nih.gov/pubmed/36712940
http://dx.doi.org/10.1093/pnasnexus/pgac270

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9830950/
https://www.ncbi.nlm.nih.gov/pubmed/36712940
http://dx.doi.org/10.1093/pnasnexus/pgac270

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