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Risk factors and microbiological features of recurrent Escherichia coli bloodstream infections

Understanding the risk factors and microbiological features in recurrent Escherichia coli BSI is helpful for clinicians. Data of patients with E. coil BSI from 2017 to 2018 were collected. Antimicrobial resistance rates of E. coli were determined. We also identified the ST131 and ESBL genotype to ev...

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Autores principales: Kim, Yong Chan, Choi, Heun, Kim, Young Ah, Park, Yoon Soo, Seo, Young Hee, Lee, Hyukmin, Lee, Kyungwon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9831297/
https://www.ncbi.nlm.nih.gov/pubmed/36626405
http://dx.doi.org/10.1371/journal.pone.0280196
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author Kim, Yong Chan
Choi, Heun
Kim, Young Ah
Park, Yoon Soo
Seo, Young Hee
Lee, Hyukmin
Lee, Kyungwon
author_facet Kim, Yong Chan
Choi, Heun
Kim, Young Ah
Park, Yoon Soo
Seo, Young Hee
Lee, Hyukmin
Lee, Kyungwon
author_sort Kim, Yong Chan
collection PubMed
description Understanding the risk factors and microbiological features in recurrent Escherichia coli BSI is helpful for clinicians. Data of patients with E. coil BSI from 2017 to 2018 were collected. Antimicrobial resistance rates of E. coli were determined. We also identified the ST131 and ESBL genotype to evaluate the molecular epidemiology of E. coli. Whole genome sequencing was conducted on the available ESBL-producing E. coli samples. Of 808 patients with E. coli BSI, 57 (6.31%) experienced recurrence; 29 developed at 4–30 days after initial BSI (early onset recurrence) and 28 at 31–270 days after initial BSI (late onset recurrence). One hundred forty-nine patients with single episode, whose samples were available for determining the molecular epidemiology, were selected for comparison. Vascular catheterization (adjusted odds ratio [aOR], 4.588; 95% confidence interval [CI], 1.049–20.068), ESBL phenotype (aOR, 2.037; 95% CI, 1.037–3.999) and SOFA score ≥9 (aOR, 3.210; 95% CI, 1.359–7.581) were independent risk factors for recurrence. The proportion of ST131 and ESBL genotype was highest in early onset recurrent BSI (41.4% and 41.4%, respectively), from which E. coil had the highest resistance rates to most antimicrobial agents. Whole genome sequencing on 27 of ESBL-producing E. coli (11 from single episode, 11 from early onset recurrence, and 5 from late onset recurrence) demonstrated that various virulence factors, resistant genes, and plasmid types existed in isolates from all types of BSI. Risk factors contributing to the recurrence and microbiological features of E. coli causing recurrent BSI may be helpful for management planning in the clinical setting.
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spelling pubmed-98312972023-01-11 Risk factors and microbiological features of recurrent Escherichia coli bloodstream infections Kim, Yong Chan Choi, Heun Kim, Young Ah Park, Yoon Soo Seo, Young Hee Lee, Hyukmin Lee, Kyungwon PLoS One Research Article Understanding the risk factors and microbiological features in recurrent Escherichia coli BSI is helpful for clinicians. Data of patients with E. coil BSI from 2017 to 2018 were collected. Antimicrobial resistance rates of E. coli were determined. We also identified the ST131 and ESBL genotype to evaluate the molecular epidemiology of E. coli. Whole genome sequencing was conducted on the available ESBL-producing E. coli samples. Of 808 patients with E. coli BSI, 57 (6.31%) experienced recurrence; 29 developed at 4–30 days after initial BSI (early onset recurrence) and 28 at 31–270 days after initial BSI (late onset recurrence). One hundred forty-nine patients with single episode, whose samples were available for determining the molecular epidemiology, were selected for comparison. Vascular catheterization (adjusted odds ratio [aOR], 4.588; 95% confidence interval [CI], 1.049–20.068), ESBL phenotype (aOR, 2.037; 95% CI, 1.037–3.999) and SOFA score ≥9 (aOR, 3.210; 95% CI, 1.359–7.581) were independent risk factors for recurrence. The proportion of ST131 and ESBL genotype was highest in early onset recurrent BSI (41.4% and 41.4%, respectively), from which E. coil had the highest resistance rates to most antimicrobial agents. Whole genome sequencing on 27 of ESBL-producing E. coli (11 from single episode, 11 from early onset recurrence, and 5 from late onset recurrence) demonstrated that various virulence factors, resistant genes, and plasmid types existed in isolates from all types of BSI. Risk factors contributing to the recurrence and microbiological features of E. coli causing recurrent BSI may be helpful for management planning in the clinical setting. Public Library of Science 2023-01-10 /pmc/articles/PMC9831297/ /pubmed/36626405 http://dx.doi.org/10.1371/journal.pone.0280196 Text en © 2023 Kim et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Kim, Yong Chan
Choi, Heun
Kim, Young Ah
Park, Yoon Soo
Seo, Young Hee
Lee, Hyukmin
Lee, Kyungwon
Risk factors and microbiological features of recurrent Escherichia coli bloodstream infections
title Risk factors and microbiological features of recurrent Escherichia coli bloodstream infections
title_full Risk factors and microbiological features of recurrent Escherichia coli bloodstream infections
title_fullStr Risk factors and microbiological features of recurrent Escherichia coli bloodstream infections
title_full_unstemmed Risk factors and microbiological features of recurrent Escherichia coli bloodstream infections
title_short Risk factors and microbiological features of recurrent Escherichia coli bloodstream infections
title_sort risk factors and microbiological features of recurrent escherichia coli bloodstream infections
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9831297/
https://www.ncbi.nlm.nih.gov/pubmed/36626405
http://dx.doi.org/10.1371/journal.pone.0280196
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