Using canavanine resistance to measure mutation rates in Schizosaccharomyces pombe

We constructed a panel of S. pombe strains expressing DNA polymerase ε variants associated with cancer, specifically POLES297F, POLEV411L, POLEL424V, POLES459F, and used these to compare mutation rates determined by canavanine resistance with other selective methods. Canavanine-resistance mutation r...

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Detalles Bibliográficos
Autores principales: Pai, Chen-Chun, Heitzer, Ellen, Bertrand, Sibyl, Toumazou, Sophia, Humphrey, Timothy C., Kearsey, Stephen E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9831302/
https://www.ncbi.nlm.nih.gov/pubmed/36626373
http://dx.doi.org/10.1371/journal.pone.0271016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9831302/
https://www.ncbi.nlm.nih.gov/pubmed/36626373
http://dx.doi.org/10.1371/journal.pone.0271016

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