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Exploring the potential of intranasally administered naturally occurring quercetin loaded into polymeric nanocapsules as a novel platform for the treatment of anxiety
Anxiety is one of the most prevalent forms of psychopathology that affects millions worldwide. It gained more importance under the pandemic status that resulted in higher anxiety prevalence. Anxiolytic drugs such as benzodiazepines have an unfavorable risk/benefit ratio resulting in a shift toward a...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9831377/ https://www.ncbi.nlm.nih.gov/pubmed/36627363 http://dx.doi.org/10.1038/s41598-023-27665-6 |
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author | Mahmoud, Khaled Y. Elhesaisy, Nahla A. Rashed, Abdelrahman R. Mikhael, Ebram S. Fadl, Mahmoud I. Elsadek, Mahmoud S. Mohamed, Merna A. Mostafa, Merna A. Hassan, Mohamed A. Halema, Omar M. Elnemer, Youssef H. Swidan, Shady A. |
author_facet | Mahmoud, Khaled Y. Elhesaisy, Nahla A. Rashed, Abdelrahman R. Mikhael, Ebram S. Fadl, Mahmoud I. Elsadek, Mahmoud S. Mohamed, Merna A. Mostafa, Merna A. Hassan, Mohamed A. Halema, Omar M. Elnemer, Youssef H. Swidan, Shady A. |
author_sort | Mahmoud, Khaled Y. |
collection | PubMed |
description | Anxiety is one of the most prevalent forms of psychopathology that affects millions worldwide. It gained more importance under the pandemic status that resulted in higher anxiety prevalence. Anxiolytic drugs such as benzodiazepines have an unfavorable risk/benefit ratio resulting in a shift toward active ingredients with better safety profile such as the naturally occurring quercetin (QRC). The delivery of QRC is hampered by its low water solubility and low bioavailability. The potential to enhance QRC delivery to the brain utilizing polymeric nanocapsules administered intranasally is investigated in the current study. Polymeric nanocapsules were prepared utilizing the nanoprecipitation technique. The best formula displayed a particle size of 227.8 ± 11.9 nm, polydispersity index of 0.466 ± 0.023, zeta potential of − 17.5 ± 0.01 mV, and encapsulation efficiency % of 92.5 ± 1.9%. In vitro release of QRC loaded polymeric nanocapsules exhibited a biphasic release with an initial burst release followed by a sustained release pattern. Behavioral testing demonstrated the superiority of QRC loaded polymeric nanocapsules administered intranasally compared to QRC dispersion administered both orally and intranasally. The prepared QRC loaded polymeric nanocapsules also demonstrated good safety profile with high tolerability. |
format | Online Article Text |
id | pubmed-9831377 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-98313772023-01-11 Exploring the potential of intranasally administered naturally occurring quercetin loaded into polymeric nanocapsules as a novel platform for the treatment of anxiety Mahmoud, Khaled Y. Elhesaisy, Nahla A. Rashed, Abdelrahman R. Mikhael, Ebram S. Fadl, Mahmoud I. Elsadek, Mahmoud S. Mohamed, Merna A. Mostafa, Merna A. Hassan, Mohamed A. Halema, Omar M. Elnemer, Youssef H. Swidan, Shady A. Sci Rep Article Anxiety is one of the most prevalent forms of psychopathology that affects millions worldwide. It gained more importance under the pandemic status that resulted in higher anxiety prevalence. Anxiolytic drugs such as benzodiazepines have an unfavorable risk/benefit ratio resulting in a shift toward active ingredients with better safety profile such as the naturally occurring quercetin (QRC). The delivery of QRC is hampered by its low water solubility and low bioavailability. The potential to enhance QRC delivery to the brain utilizing polymeric nanocapsules administered intranasally is investigated in the current study. Polymeric nanocapsules were prepared utilizing the nanoprecipitation technique. The best formula displayed a particle size of 227.8 ± 11.9 nm, polydispersity index of 0.466 ± 0.023, zeta potential of − 17.5 ± 0.01 mV, and encapsulation efficiency % of 92.5 ± 1.9%. In vitro release of QRC loaded polymeric nanocapsules exhibited a biphasic release with an initial burst release followed by a sustained release pattern. Behavioral testing demonstrated the superiority of QRC loaded polymeric nanocapsules administered intranasally compared to QRC dispersion administered both orally and intranasally. The prepared QRC loaded polymeric nanocapsules also demonstrated good safety profile with high tolerability. Nature Publishing Group UK 2023-01-10 /pmc/articles/PMC9831377/ /pubmed/36627363 http://dx.doi.org/10.1038/s41598-023-27665-6 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Mahmoud, Khaled Y. Elhesaisy, Nahla A. Rashed, Abdelrahman R. Mikhael, Ebram S. Fadl, Mahmoud I. Elsadek, Mahmoud S. Mohamed, Merna A. Mostafa, Merna A. Hassan, Mohamed A. Halema, Omar M. Elnemer, Youssef H. Swidan, Shady A. Exploring the potential of intranasally administered naturally occurring quercetin loaded into polymeric nanocapsules as a novel platform for the treatment of anxiety |
title | Exploring the potential of intranasally administered naturally occurring quercetin loaded into polymeric nanocapsules as a novel platform for the treatment of anxiety |
title_full | Exploring the potential of intranasally administered naturally occurring quercetin loaded into polymeric nanocapsules as a novel platform for the treatment of anxiety |
title_fullStr | Exploring the potential of intranasally administered naturally occurring quercetin loaded into polymeric nanocapsules as a novel platform for the treatment of anxiety |
title_full_unstemmed | Exploring the potential of intranasally administered naturally occurring quercetin loaded into polymeric nanocapsules as a novel platform for the treatment of anxiety |
title_short | Exploring the potential of intranasally administered naturally occurring quercetin loaded into polymeric nanocapsules as a novel platform for the treatment of anxiety |
title_sort | exploring the potential of intranasally administered naturally occurring quercetin loaded into polymeric nanocapsules as a novel platform for the treatment of anxiety |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9831377/ https://www.ncbi.nlm.nih.gov/pubmed/36627363 http://dx.doi.org/10.1038/s41598-023-27665-6 |
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