Cargando…

High Expression of DNTTIP1 Predicts Poor Prognosis in Clear Cell Renal Cell Carcinoma

BACKGROUND: Invasion and metastasis led to poor prognosis and death of clear cell renal cell carcinoma (ccRCC) patients. The deoxynucleotidyl transferase terminal interacting protein 1 (DNTTIP1) was reported to promote multiple tumor progression. However, there is no research about DNTTIP1 in ccRCC....

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Xuegang, Li, Weiquan, Lou, Ning, Han, Weiwei, Hai, Bo, Xiao, Wen, Zhang, Xiaoping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9831534/
https://www.ncbi.nlm.nih.gov/pubmed/36636625
http://dx.doi.org/10.2147/PGPM.S382843
_version_ 1784867870895767552
author Wang, Xuegang
Li, Weiquan
Lou, Ning
Han, Weiwei
Hai, Bo
Xiao, Wen
Zhang, Xiaoping
author_facet Wang, Xuegang
Li, Weiquan
Lou, Ning
Han, Weiwei
Hai, Bo
Xiao, Wen
Zhang, Xiaoping
author_sort Wang, Xuegang
collection PubMed
description BACKGROUND: Invasion and metastasis led to poor prognosis and death of clear cell renal cell carcinoma (ccRCC) patients. The deoxynucleotidyl transferase terminal interacting protein 1 (DNTTIP1) was reported to promote multiple tumor progression. However, there is no research about DNTTIP1 in ccRCC. METHODS: Kaplan–Meier survival analysis, multivariate analysis demonstrated the prognostic indicator in overall survival (OS) and disease-free survival (DFS) of ccRCC with DNTTIP1 expression in the Cancer Genome Atlas Kidney Clear Cell Carcinoma (TCGA-KIRC). Receiver operator characteristic (ROC) curve analyzed diagnostic ability of DNTTIP1 in TCGA-KIRC and validation dataset. The quantitative real-time polymerase chain reaction (qRT-PCR) detected the DNTTIP1 expression in renal cancer tissues, and the Office of Cancer Clinical Proteomics Research (CPTAC) verified the protein expression of DNTTIP1. Moreover, nomogram predicted the role of DNTTIP1 in ccRCC patient. Single-sample Gene Set Enrichment Analysis (SsGSEA) and GSEA evaluated the pathogenesis role of DNTTIP1 in TCGA-KIRC. RESULTS: DNTTIP1 expression was higher in ccRCC tumor tissues. High expression of DNTTIP1 was associated with poor OS (HR = 1.618, P < 0.0001), and poor DFS (HR = 1.789, P < 0.0001). SsGSEA and GSEA showed DNTTIP1 was associated with hypoxia, epithelial-mesenchymal transition (EMT), angiogenesis, G2M checkpoint. DNTTIP1 had a positive correlation with EMT biomarkers in ccRCC, and might be an effective target for ccRCC. CONCLUSION: This study provided that higher expression of DNTTIP1 predicted poor prognosis in ccRCC, and DNTTIP1 might be a novel detection biomarker and therapeutic target of tumor malignant in the future.
format Online
Article
Text
id pubmed-9831534
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Dove
record_format MEDLINE/PubMed
spelling pubmed-98315342023-01-11 High Expression of DNTTIP1 Predicts Poor Prognosis in Clear Cell Renal Cell Carcinoma Wang, Xuegang Li, Weiquan Lou, Ning Han, Weiwei Hai, Bo Xiao, Wen Zhang, Xiaoping Pharmgenomics Pers Med Original Research BACKGROUND: Invasion and metastasis led to poor prognosis and death of clear cell renal cell carcinoma (ccRCC) patients. The deoxynucleotidyl transferase terminal interacting protein 1 (DNTTIP1) was reported to promote multiple tumor progression. However, there is no research about DNTTIP1 in ccRCC. METHODS: Kaplan–Meier survival analysis, multivariate analysis demonstrated the prognostic indicator in overall survival (OS) and disease-free survival (DFS) of ccRCC with DNTTIP1 expression in the Cancer Genome Atlas Kidney Clear Cell Carcinoma (TCGA-KIRC). Receiver operator characteristic (ROC) curve analyzed diagnostic ability of DNTTIP1 in TCGA-KIRC and validation dataset. The quantitative real-time polymerase chain reaction (qRT-PCR) detected the DNTTIP1 expression in renal cancer tissues, and the Office of Cancer Clinical Proteomics Research (CPTAC) verified the protein expression of DNTTIP1. Moreover, nomogram predicted the role of DNTTIP1 in ccRCC patient. Single-sample Gene Set Enrichment Analysis (SsGSEA) and GSEA evaluated the pathogenesis role of DNTTIP1 in TCGA-KIRC. RESULTS: DNTTIP1 expression was higher in ccRCC tumor tissues. High expression of DNTTIP1 was associated with poor OS (HR = 1.618, P < 0.0001), and poor DFS (HR = 1.789, P < 0.0001). SsGSEA and GSEA showed DNTTIP1 was associated with hypoxia, epithelial-mesenchymal transition (EMT), angiogenesis, G2M checkpoint. DNTTIP1 had a positive correlation with EMT biomarkers in ccRCC, and might be an effective target for ccRCC. CONCLUSION: This study provided that higher expression of DNTTIP1 predicted poor prognosis in ccRCC, and DNTTIP1 might be a novel detection biomarker and therapeutic target of tumor malignant in the future. Dove 2023-01-06 /pmc/articles/PMC9831534/ /pubmed/36636625 http://dx.doi.org/10.2147/PGPM.S382843 Text en © 2023 Wang et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Wang, Xuegang
Li, Weiquan
Lou, Ning
Han, Weiwei
Hai, Bo
Xiao, Wen
Zhang, Xiaoping
High Expression of DNTTIP1 Predicts Poor Prognosis in Clear Cell Renal Cell Carcinoma
title High Expression of DNTTIP1 Predicts Poor Prognosis in Clear Cell Renal Cell Carcinoma
title_full High Expression of DNTTIP1 Predicts Poor Prognosis in Clear Cell Renal Cell Carcinoma
title_fullStr High Expression of DNTTIP1 Predicts Poor Prognosis in Clear Cell Renal Cell Carcinoma
title_full_unstemmed High Expression of DNTTIP1 Predicts Poor Prognosis in Clear Cell Renal Cell Carcinoma
title_short High Expression of DNTTIP1 Predicts Poor Prognosis in Clear Cell Renal Cell Carcinoma
title_sort high expression of dnttip1 predicts poor prognosis in clear cell renal cell carcinoma
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9831534/
https://www.ncbi.nlm.nih.gov/pubmed/36636625
http://dx.doi.org/10.2147/PGPM.S382843
work_keys_str_mv AT wangxuegang highexpressionofdnttip1predictspoorprognosisinclearcellrenalcellcarcinoma
AT liweiquan highexpressionofdnttip1predictspoorprognosisinclearcellrenalcellcarcinoma
AT louning highexpressionofdnttip1predictspoorprognosisinclearcellrenalcellcarcinoma
AT hanweiwei highexpressionofdnttip1predictspoorprognosisinclearcellrenalcellcarcinoma
AT haibo highexpressionofdnttip1predictspoorprognosisinclearcellrenalcellcarcinoma
AT xiaowen highexpressionofdnttip1predictspoorprognosisinclearcellrenalcellcarcinoma
AT zhangxiaoping highexpressionofdnttip1predictspoorprognosisinclearcellrenalcellcarcinoma