Computational design of peptides to target Na(V)1.7 channel with high potency and selectivity for the treatment of pain

The voltage-gated sodium Na(V)1.7 channel plays a key role as a mediator of action potential propagation in C-fiber nociceptors and is an established molecular target for pain therapy. ProTx-II is a potent and moderately selective peptide toxin from tarantula venom that inhibits human Na(V)1.7 activ...

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Detalles Bibliográficos
Autores principales: Nguyen, Phuong T, Nguyen, Hai M, Wagner, Karen M, Stewart, Robert G, Singh, Vikrant, Thapa, Parashar, Chen, Yi-Je, Lillya, Mark W, Ton, Anh Tuan, Kondo, Richard, Ghetti, Andre, Pennington, Michael W, Hammock, Bruce, Griffith, Theanne N, Sack, Jon T, Wulff, Heike, Yarov-Yarovoy, Vladimir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9831606/
https://www.ncbi.nlm.nih.gov/pubmed/36576241
http://dx.doi.org/10.7554/eLife.81727

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