CROCCP2 acts as a human-specific modifier of cilia dynamics and mTOR signaling to promote expansion of cortical progenitors

The primary cilium is a central signaling component during embryonic development. Here we focus on CROCCP2, a hominid-specific gene duplicate from ciliary rootlet coiled coil (CROCC), also known as rootletin, that encodes the major component of the ciliary rootlet. We find that CROCCP2 is highly exp...

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Detalles Bibliográficos
Autores principales: Van Heurck, Roxane, Bonnefont, Jérôme, Wojno, Marta, Suzuki, Ikuo K., Velez-Bravo, Fausto D., Erkol, Emir, Nguyen, Dan Truc, Herpoel, Adèle, Bilheu, Angéline, Beckers, Sofie, Ledent, Catherine, Vanderhaeghen, Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9831670/
https://www.ncbi.nlm.nih.gov/pubmed/36334595
http://dx.doi.org/10.1016/j.neuron.2022.10.018

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