A novel long noncoding RNA AC092718.4 as a prognostic biomarker and promotes lung adenocarcinoma progression

Long noncoding RNAs (lncRNAs) reportedly play critical roles in the pathogenesis of various cancers, including lung adenocarcinoma (LUAD). However, the expression level, clinical significance, and potential function of lncRNA-AC092718.4 in LUAD remain unclear. In this study, we found that AC092718.4...

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Autores principales: Chen, Siqin, Yu, Yang, Yuan, Yixiao, Chen, Xi, Zhou, Fan, Li, Yongwu, Wang, Ping, Jiang, Xiulin, Tian, Sha, Ren, Wenjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9831730/
https://www.ncbi.nlm.nih.gov/pubmed/36490353
http://dx.doi.org/10.18632/aging.204426
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author Chen, Siqin
Yu, Yang
Yuan, Yixiao
Chen, Xi
Zhou, Fan
Li, Yongwu
Wang, Ping
Jiang, Xiulin
Tian, Sha
Ren, Wenjun
author_facet Chen, Siqin
Yu, Yang
Yuan, Yixiao
Chen, Xi
Zhou, Fan
Li, Yongwu
Wang, Ping
Jiang, Xiulin
Tian, Sha
Ren, Wenjun
author_sort Chen, Siqin
collection PubMed
description Long noncoding RNAs (lncRNAs) reportedly play critical roles in the pathogenesis of various cancers, including lung adenocarcinoma (LUAD). However, the expression level, clinical significance, and potential function of lncRNA-AC092718.4 in LUAD remain unclear. In this study, we found that AC092718.4 was highly expressed in LUAD and high expression of AC092718.4 was correlated with poor overall survival (OS) and disease-specific survival (DSS) in LUAD. Cox regression analysis confirmed that AC092718.4 was an independent factor for LUAD prognosis. Kyoto Encyclopedia of Genes and Genomes (KEGG) results showed that AC092718.4 was involved in the PI3K-Akt signaling pathway, Th17 cell differentiation, and cell apoptosis. AC092718.4 expression was correlated with immune cell infiltration. Finally, we found that the knockdown of AC092718.4 inhibited lung adenocarcinoma (LUAD) cell growth and promote cell apoptosis. Our findings confirmed that AC092718.4 may serve as a potential prognostic biomarker in LUAD.
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spelling pubmed-98317302023-01-11 A novel long noncoding RNA AC092718.4 as a prognostic biomarker and promotes lung adenocarcinoma progression Chen, Siqin Yu, Yang Yuan, Yixiao Chen, Xi Zhou, Fan Li, Yongwu Wang, Ping Jiang, Xiulin Tian, Sha Ren, Wenjun Aging (Albany NY) Research Paper Long noncoding RNAs (lncRNAs) reportedly play critical roles in the pathogenesis of various cancers, including lung adenocarcinoma (LUAD). However, the expression level, clinical significance, and potential function of lncRNA-AC092718.4 in LUAD remain unclear. In this study, we found that AC092718.4 was highly expressed in LUAD and high expression of AC092718.4 was correlated with poor overall survival (OS) and disease-specific survival (DSS) in LUAD. Cox regression analysis confirmed that AC092718.4 was an independent factor for LUAD prognosis. Kyoto Encyclopedia of Genes and Genomes (KEGG) results showed that AC092718.4 was involved in the PI3K-Akt signaling pathway, Th17 cell differentiation, and cell apoptosis. AC092718.4 expression was correlated with immune cell infiltration. Finally, we found that the knockdown of AC092718.4 inhibited lung adenocarcinoma (LUAD) cell growth and promote cell apoptosis. Our findings confirmed that AC092718.4 may serve as a potential prognostic biomarker in LUAD. Impact Journals 2022-12-07 /pmc/articles/PMC9831730/ /pubmed/36490353 http://dx.doi.org/10.18632/aging.204426 Text en Copyright: © 2022 Chen et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Chen, Siqin
Yu, Yang
Yuan, Yixiao
Chen, Xi
Zhou, Fan
Li, Yongwu
Wang, Ping
Jiang, Xiulin
Tian, Sha
Ren, Wenjun
A novel long noncoding RNA AC092718.4 as a prognostic biomarker and promotes lung adenocarcinoma progression
title A novel long noncoding RNA AC092718.4 as a prognostic biomarker and promotes lung adenocarcinoma progression
title_full A novel long noncoding RNA AC092718.4 as a prognostic biomarker and promotes lung adenocarcinoma progression
title_fullStr A novel long noncoding RNA AC092718.4 as a prognostic biomarker and promotes lung adenocarcinoma progression
title_full_unstemmed A novel long noncoding RNA AC092718.4 as a prognostic biomarker and promotes lung adenocarcinoma progression
title_short A novel long noncoding RNA AC092718.4 as a prognostic biomarker and promotes lung adenocarcinoma progression
title_sort novel long noncoding rna ac092718.4 as a prognostic biomarker and promotes lung adenocarcinoma progression
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9831730/
https://www.ncbi.nlm.nih.gov/pubmed/36490353
http://dx.doi.org/10.18632/aging.204426
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