N6-methyladenine RNA Methylation Epigenetic Modification and Kidney Diseases

RNA methylation modification is a rapidly developing field in epigenetics. N6-methyladensine (m(6)A) is the most common internal modification in eukaryotic mRNA. m(6)A group regulates RNA splicing, stability, translocation, and translation. Enzymes catalyzing this process were termed as writers, era...

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Detalles Bibliográficos
Autores principales: Luan, Junjun, Kopp, Jeffrey B., Zhou, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9831943/
https://www.ncbi.nlm.nih.gov/pubmed/36644366
http://dx.doi.org/10.1016/j.ekir.2022.10.009
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author Luan, Junjun
Kopp, Jeffrey B.
Zhou, Hua
author_facet Luan, Junjun
Kopp, Jeffrey B.
Zhou, Hua
author_sort Luan, Junjun
collection PubMed
description RNA methylation modification is a rapidly developing field in epigenetics. N6-methyladensine (m(6)A) is the most common internal modification in eukaryotic mRNA. m(6)A group regulates RNA splicing, stability, translocation, and translation. Enzymes catalyzing this process were termed as writers, erasers, and readers. Recent studies have focused on exploring the role of RNA methylation in human diseases. RNA methylation modifications, particularly m(6)A, play important roles in the pathogenesis of kidney diseases. In this review, we provide a brief description of m(6)A and summarize the impact of m(6)A on acute and chronic kidney disease (CKD) and possible future study directions for this research.
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spelling pubmed-98319432023-01-12 N6-methyladenine RNA Methylation Epigenetic Modification and Kidney Diseases Luan, Junjun Kopp, Jeffrey B. Zhou, Hua Kidney Int Rep Review RNA methylation modification is a rapidly developing field in epigenetics. N6-methyladensine (m(6)A) is the most common internal modification in eukaryotic mRNA. m(6)A group regulates RNA splicing, stability, translocation, and translation. Enzymes catalyzing this process were termed as writers, erasers, and readers. Recent studies have focused on exploring the role of RNA methylation in human diseases. RNA methylation modifications, particularly m(6)A, play important roles in the pathogenesis of kidney diseases. In this review, we provide a brief description of m(6)A and summarize the impact of m(6)A on acute and chronic kidney disease (CKD) and possible future study directions for this research. Elsevier 2022-10-17 /pmc/articles/PMC9831943/ /pubmed/36644366 http://dx.doi.org/10.1016/j.ekir.2022.10.009 Text en © 2022 Published by Elsevier Inc. on behalf of the International Society of Nephrology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Luan, Junjun
Kopp, Jeffrey B.
Zhou, Hua
N6-methyladenine RNA Methylation Epigenetic Modification and Kidney Diseases
title N6-methyladenine RNA Methylation Epigenetic Modification and Kidney Diseases
title_full N6-methyladenine RNA Methylation Epigenetic Modification and Kidney Diseases
title_fullStr N6-methyladenine RNA Methylation Epigenetic Modification and Kidney Diseases
title_full_unstemmed N6-methyladenine RNA Methylation Epigenetic Modification and Kidney Diseases
title_short N6-methyladenine RNA Methylation Epigenetic Modification and Kidney Diseases
title_sort n6-methyladenine rna methylation epigenetic modification and kidney diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9831943/
https://www.ncbi.nlm.nih.gov/pubmed/36644366
http://dx.doi.org/10.1016/j.ekir.2022.10.009
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