Molecular Mechanisms of Rhabdomyolysis-Induced Kidney Injury: From Bench to Bedside

Rhabdomyolysis-induced acute kidney injury (RIAKI) occurs following damage to the muscular sarcolemma sheath, resulting in the leakage of myoglobin and other metabolites that cause kidney damage. Currently, the sole recommended clinical treatment for RIAKI is aggressive fluid resuscitation, but othe...

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Detalles Bibliográficos
Autores principales: Hebert, Jessica F., Burfeind, Kevin G., Malinoski, Darren, Hutchens, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9831947/
https://www.ncbi.nlm.nih.gov/pubmed/36644345
http://dx.doi.org/10.1016/j.ekir.2022.09.026
Descripción
Sumario:Rhabdomyolysis-induced acute kidney injury (RIAKI) occurs following damage to the muscular sarcolemma sheath, resulting in the leakage of myoglobin and other metabolites that cause kidney damage. Currently, the sole recommended clinical treatment for RIAKI is aggressive fluid resuscitation, but other potential therapies, including pretreatments for those at risk for developing RIAKI, are under investigation. This review outlines the mechanisms and clinical significance of RIAKI, investigational treatments and their specific targets, and the status of ongoing research trials.

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